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The Role of Neurotrophic Factors in Pathophysiology of Major Depressive Disorder Publisher Pubmed



Amidfar M1 ; Reus GZ2 ; De Moura AB2 ; Quevedo J3, 4 ; Kim YK5
Authors
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Authors Affiliations
  1. 1. Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina, Criciuma, Santa Catarina, Brazil
  3. 3. UT Health Center of Excellence on Mood Disorders, Faillace Department of Psychiatry & Behavioral Sciences, McGovern Medical School, Houston, TX, United States
  4. 4. Translational Psychiatry Program, Faillace Department of Psychiatry & Behavioral Sciences, McGovern Medical School, Houston, TX, United States
  5. 5. Department of Psychiatry, Korea University Ansan Hospital, College of Medicine, Ansan, South Korea

Source: Advances in Experimental Medicine and Biology Published:2021


Abstract

According to the neurotrophic hypothesis of major depressive disorder (MDD), impairment in growth factor signaling might be associated with the pathology of this illness. Current evidence demonstrates that impaired neuroplasticity induced by alterations of neurotrophic growth factors and related signaling pathways may be underlying to the pathophysiology of MDD. Brain-derived neurotrophic factor (BDNF) is the most studied neurotrophic factor involved in the neurobiology of MDD. Nevertheless, developing evidence has implicated other neurotrophic factors, including neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), nerve growth factor (NGF), vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), glial cell-derived neurotrophic factor (GDNF), and fibroblast growth factor (FGF) in the MDD pathophysiology. Here, we summarize the current literature on the involvement of neurotrophic factors and related signaling pathways in the pathophysiology of MDD. © 2021, Springer Nature Singapore Pte Ltd.
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