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Sex Steroids-Induced Neurogenesis in Adult Brain: A Better Look at Mechanisms and Mediators Publisher Pubmed



Abotalebi H1 ; Ebrahimi B2 ; Shahriyari R1 ; Shafieian R1
Authors
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Authors Affiliations
  1. 1. Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Anatomy and Cell Biology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Hormone Molecular Biology and Clinical Investigation Published:2021


Abstract

Adult neurogenesis is the production of new nerve cells in the adult brain. Neurogenesis is a clear example of the neuroplasticity phenomenon which can be observed in most of mammalian species, including human beings. This phenomenon occurs, at least, in two regions of the brain: the subgranular zone of the dentate gyrus in hippocampus and the ventricular zone of lateral ventricles. Numerous studies have investigated the relationship between sex steroid hormones and neurogenesis of adult brain; of which, mostly concentrated on the role of estradiol. It has been shown that estrogen plays a significant role in this process through both classic and non-classic mechanisms, including a variety of different growth factors. Therefore, the objective of this review is to investigate the role of female sex steroids with an emphasis on estradiol and also its potential implications for regulating the neurogenesis in the adult brain. © 2021 Walter de Gruyter GmbH, Berlin/Boston 2021.
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