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Bioactive Chitosan/Poly(Ethyleneoxide)/Cufe2o4 Nanofibers for Potential Wound Healing Publisher Pubmed



Sharifi E1, 2 ; Jamaledin R3 ; Familsattarian F4 ; Nejaddehbashi F5 ; Bagheri M6 ; Chehelgerdi M7, 8 ; Nazarzadeh Zare E9 ; Akhavan O3
Authors
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Authors Affiliations
  1. 1. Cancer Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
  4. 4. Department of Materials Engineering, Bu-Ali Sina University, P.O.B: 65178-38695, Hamedan, Iran
  5. 5. Cellular and Molecular Research Center, Medical Basic Sciences Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Tissue Engineering and Applied Cellular Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Novin Genome (NG) Lab, Research and Development Center for Biotechnology, Shahrekord, Iran
  8. 8. Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
  9. 9. School of Chemistry, Damghan University, Damghan, 36716-45667, Iran

Source: Environmental Research Published:2023


Abstract

Wound healing is a complex process that often requires intervention to accelerate tissue regeneration and prevent complications. The goal of this research was to assess the potential of bioactive chitosan@poly (ethylene oxide)@CuFe2O4 (CS@PEO@CF) nanofibers for wound healing applications by evaluating their morphology, mechanical properties, and magnetic behavior. Additionally, in vitro and in vivo studies were conducted to investigate their effectiveness in promoting wound healing treatment. The nanoparticles exhibited remarkable antibacterial and antioxidant properties. In the nanofibrous mats, the optimal concentration of CuFe2O4 was determined to be 0.1% Wt/V. Importantly, this concentration did not adversely affect the viability of fibroblast cells, which also identified the ideal concentration. The scaffold's hemocompatibility revealed nonhemolytic properties. Additionally, a wound-healing experiment demonstrated significant migration and growth of fibroblast cells at the edge of the wound. These nanofibrous mats are applied to treat rats with full-thickness excisional wounds. Histopathological analysis of these wounds showed enhanced wound healing ability, as well as regeneration of sebaceous glands and hair follicles within the skin. Overall, the developed wound dressing comprises CuFe2O4 nanoparticles incorporated into CS/PEO nanofibrous mats demonstrating its potential for successful application in wound treatment. © 2023 Elsevier Inc.
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