Chitosan Decorated Cobalt Zinc Ferrite Nanoferrofluid Composites for Potential Cancer Hyperthermia Therapy: Anti-Cancer Activity, Genotoxicity, and Immunotoxicity Evaluation

Chitosan Decorated Cobalt Zinc Ferrite Nanoferrofluid Composites for Potential Cancer Hyperthermia Therapy: Anti-Cancer Activity, Genotoxicity, and Immunotoxicity Evaluation Publisher

Sharifi E^{1, 2} ; Reisi F^{1, 3} ; Yousefiasl S⁴ ; Elahian F⁵ ; Barjui SP¹ ; Sartorius R⁶ ; Fattahi N⁷ ; Zare EN⁸ ; Rabiee N^{9, 10} ; Gazi EP⁵ ; Paivasantos AC^{11, 12} ; Parlanti P¹³ ; Gemmi M¹³ ; Mobini GR¹ Show All Authors

Sharifi E^{1, 2}
Reisi F^{1, 3}
Yousefiasl S⁴
Elahian F⁵
Barjui SP¹
Sartorius R⁶
Fattahi N⁷
Zare EN⁸
Rabiee N^{9, 10}
Gazi EP⁵
Paivasantos AC^{11, 12}
Parlanti P¹³
Gemmi M¹³
Mobini GR¹
Hashemzadehchaleshtori M¹
De Berardinis P⁶
Sharifi I¹⁴
Mattoli V¹³
Makvandi P¹⁵

Show Affiliations

1. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
2. Cancer Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
3. Pasteur Institute of Iran (IPI), Tehran, Iran
4. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
5. Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran
6. Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Naples, 80131, Italy
7. Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
8. School of Chemistry, Damghan University, Damghan, 36716-45667, Iran
9. School of Engineering, Macquarie University, Sydney, 2109, NSW, Australia
10. Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, 6150, WA, Australia
11. Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, University of Coimbra, Azinhaga Sta. Comba, Coimbra, 3000-548, Portugal
12. LAQV, REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Azinhaga Sta. Comba, Coimbra, 3000-548, Portugal
13. Center for Materials Interfaces, Istituto Italiano di Tecnologia, Viale Rinaldo Piaggio 34, Pontedera, Pisa, 56025, Italy
14. Department of Materials Engineering, Faculty of Engineering, Shahrekord University, Shahrekord, Iran
15. The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou Peopleâ€™s Hospital, Zhejiang, Quzhou, 324000, China

Source: Advanced Composites and Hybrid Materials Published:2023

Abstract

Cancer, as the leading cause of death worldwide, has been constantly increasing in mortality every year. Among several therapeutics, nanoscale compounds showed promising results in overcoming cancer diseases. There are numerous types of research on the paramagnetic nanoparticles of iron oxide, which cause apoptosis and cancer cell death. In this study, cobalt/zinc/ferrite nanoferrofluid composites (~ 39 nm) were synthesized and decorated with chitosan to enhance the cell entry for potential applications in cancer therapy. The neat and chitosan-adorned cobalt zinc ferrite nanoferrofluid composites (~ 94 nm) displayed superparamagnetic properties. The nanocomposite exhibited anti-cancer activity against WEHI164 cancer cells in a dose- and time-dependent manner. The chitosan-coated nanocomposite was found to induce oxidative stress in WEHI164 cancer cells, as indicated by reactive oxygen species (ROS) production. Furthermore, DNA damage was indicated in WEHI164 cancer cells after exposure to chitosan-coated nanocomposites. Chitosan-coated nanocomposites promoted dendritic cell maturation by inducing the release of interleukin-6 proinflammatory cytokines. According to the results and ancillary studies, superparamagnetic nanoparticles coated with chitosan can be considered an effective and promising treatment for the destruction of cancer cells. Graphical Abstract: [Figure not available: see fulltext.] Summary: Chitosan decorated cobalt zinc ferrite nanoferrofluid composites was fabricated for potential cancer hyperthermia therapy with high biocompatibility. © 2023, The Author(s).

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Style	Citing Format
MLA	Sharifi E, et al.. "Chitosan Decorated Cobalt Zinc Ferrite Nanoferrofluid Composites for Potential Cancer Hyperthermia Therapy: Anti-Cancer Activity, Genotoxicity, and Immunotoxicity Evaluation." Advanced Composites and Hybrid Materials, vol. 6, no. 6, 2023, pp. -.
APA	Sharifi E, Reisi F, Yousefiasl S, Elahian F, Barjui SP, Sartorius R, Fattahi N, Zare EN, Rabiee N, Gazi EP, Paivasantos AC, Parlanti P, Gemmi M, Mobini GR, Hashemzadehchaleshtori M, De Berardinis P, Sharifi I, Mattoli V, Makvandi P (2023). Chitosan Decorated Cobalt Zinc Ferrite Nanoferrofluid Composites for Potential Cancer Hyperthermia Therapy: Anti-Cancer Activity, Genotoxicity, and Immunotoxicity Evaluation. Advanced Composites and Hybrid Materials, 6(6), -.
Chicago	Sharifi E, Reisi F, Yousefiasl S, Elahian F, Barjui SP, Sartorius R, Fattahi N, et al.. "Chitosan Decorated Cobalt Zinc Ferrite Nanoferrofluid Composites for Potential Cancer Hyperthermia Therapy: Anti-Cancer Activity, Genotoxicity, and Immunotoxicity Evaluation." Advanced Composites and Hybrid Materials 6, no. 6 (2023): -.
Harvard	Sharifi E et al. (2023) 'Chitosan Decorated Cobalt Zinc Ferrite Nanoferrofluid Composites for Potential Cancer Hyperthermia Therapy: Anti-Cancer Activity, Genotoxicity, and Immunotoxicity Evaluation', Advanced Composites and Hybrid Materials, 6(6), pp. -.
Vancouver	Sharifi E, Reisi F, Yousefiasl S, Elahian F, Barjui SP, Sartorius R, et al.. Chitosan Decorated Cobalt Zinc Ferrite Nanoferrofluid Composites for Potential Cancer Hyperthermia Therapy: Anti-Cancer Activity, Genotoxicity, and Immunotoxicity Evaluation. Advanced Composites and Hybrid Materials. 2023;6(6):-.
BibTex	@article{ author = {Sharifi E and Reisi F and Yousefiasl S and Elahian F and Barjui SP and Sartorius R and Fattahi N and Zare EN and Rabiee N and Gazi EP and Paivasantos AC and Parlanti P and Gemmi M and Mobini GR and Hashemzadehchaleshtori M and De Berardinis P and Sharifi I and Mattoli V and Makvandi P}, title = {Chitosan Decorated Cobalt Zinc Ferrite Nanoferrofluid Composites for Potential Cancer Hyperthermia Therapy: Anti-Cancer Activity, Genotoxicity, and Immunotoxicity Evaluation}, journal = {Advanced Composites and Hybrid Materials}, volume = {6}, number = {6}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Sharifi E AU - Reisi F AU - Yousefiasl S AU - Elahian F AU - Barjui SP AU - Sartorius R AU - Fattahi N AU - Zare EN AU - Rabiee N AU - Gazi EP AU - Paivasantos AC AU - Parlanti P AU - Gemmi M AU - Mobini GR AU - Hashemzadehchaleshtori M AU - De Berardinis P AU - Sharifi I AU - Mattoli V AU - Makvandi P TI - Chitosan Decorated Cobalt Zinc Ferrite Nanoferrofluid Composites for Potential Cancer Hyperthermia Therapy: Anti-Cancer Activity, Genotoxicity, and Immunotoxicity Evaluation JO - Advanced Composites and Hybrid Materials VL - 6 IS - 6 SP - EP - PY - 2023 ER -

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