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A Comprehensive Review of the Role of Lncrnas in Gastric Cancer (Gc) Pathogenesis, Immune Regulation, and Their Clinical Applications Publisher Pubmed



Siri G1 ; Yazdani O2 ; Esbati R2 ; Akhavanfar R3 ; Asadi F4 ; Adili A5, 6 ; Ebrahimzadeh F7 ; Hosseini SME1
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Authors Affiliations
  1. 1. Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Genetics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
  5. 5. Senior Adult Oncology Department, Moffitt Cancer Center, University of South Florida, Tampa, FL, United States
  6. 6. Department of Oncology, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Gastric cancer (GC) is the fifth most common malignant tumor and the third leading cause of cancer-related deaths worldwide. Although numerous studies have been conducted on advanced GC, the molecular mechanisms behind it remain obscure. Long non-coding RNAs (lncRNAs) are a family of RNA transcripts capable of regulating target genes at transcriptional, post-transcriptional, and translational stages. They do this by modifying mRNAs, miRNAs, and proteins. These RNAs are critical regulators of many biological processes, including gene epigenetics, transcription, and post-transcriptional levels. This article highlights recent results on lncRNAs involved in drug resistance, proliferation, migration, angiogenesis, apoptosis, autophagy, and immune response in GC. The potential clinical implications of lncRNAs as biomarkers and therapeutic targets in GC are also discussed. © 2022 Elsevier GmbH
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