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Cdkn2b-As1 As a Novel Therapeutic Target in Cancer: Mechanism and Clinical Perspective Publisher Pubmed



Hjazi A1 ; Ghaffar E2 ; Asghar W3 ; Alauldeen Khalaf H4 ; Ikram Ullah M5 ; Mireya Romeroparra R6 ; Hussien BM7 ; Abdulally Abdulhussien Alazbjee A8 ; Singh Bisht Y9 ; Fakri Mustafa Y10 ; Reza Hosseinifard S11
Authors
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Authors Affiliations
  1. 1. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  2. 2. Fatima Jinnah Medical University, Lahore, Pakistan
  3. 3. Rai Medical College Sargodha, Pakistan
  4. 4. College of Pharmacy, Al-Bayan University, Baghdad, Iraq
  5. 5. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Aljouf, Sakaka, 75471, Saudi Arabia
  6. 6. Universidad Continental, Lima, Peru
  7. 7. Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
  8. 8. Collage of Medicin, Al-Ayen University, Thi-Qar, Iraq
  9. 9. Uttaranchal Institute of Technology, Uttaranchal University, Dehradun, 248007, India
  10. 10. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq
  11. 11. Biochemistry Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Biochemical Pharmacology Published:2023


Abstract

Long non-coding RNAs (lncRNA) have been identified as essential components having considerable modulatory impacts on biological activities through altering gene transcription, epigenetic changes, and protein translation. Cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), a recently discovered lncRNA, was shown to be substantially elevated in various cancers. Furthermore, via modulation of various signaling axes, it is effectively connected to the control of critical cancer-associated biological pathways like cell proliferation, apoptosis, cell cycle, epithelial–mesenchymal transition (EMT), invasion, and migration. Considering the crucial functions of CDKN2B-AS1 in cancer onset and development, this lncRNA offers immense therapeutic implications for usage as a new diagnostic or treatment approach. In this article, we evaluate the most recent discoveries made into the functions of the lncRNA CDKN2B-AS1 in cancer, in addition to its prospect as beneficial properties, prognostic and diagnostic biomarkers in the cancer-related treatment, emphasizing its participation in a broad network of signaling axes which could affect various cancers and investigating its promising therapeutic possibility. © 2023 Elsevier Inc.
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