Status of Tnf-Α and Il-6 As Pro-Inflammatory Cytokines in Exhaled Breath Condensate of Late Adolescents With Asthma and Healthy in the Dust Storm and Non-Dust Storm Conditions

Status of Tnf-Α and Il-6 As Pro-Inflammatory Cytokines in Exhaled Breath Condensate of Late Adolescents With Asthma and Healthy in the Dust Storm and Non-Dust Storm Conditions Publisher Pubmed

Ghozikali MG^{1, 2, 3} ; Ansarin K² ; Naddafi K^{3, 4} ; Nabizadeh R^{3, 4} ; Yaghmaeian K³ ; Jaafari J⁵ ; Dehghanzadeh R¹ ; Atafar Z⁶ ; Faraji M⁷ ; Mohammadi A⁸ ; Goudarzi G⁹ ; Yunesian M^{3, 10}

Show Affiliations

1. Health and Environment Research Center, Tabriz university of Medical Sciences, Tabriz, Iran
2. Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4. Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran
5. School of Health, Guilan University of Medical Sciences, Rasht, Iran
6. Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences, Kermanshah, Iran
7. Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran
8. Department of Environmental Health Engineering, Neyshabur University of Medical Sciences, Neyshabur, Iran
9. Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
10. Department of Research Methodology and Data Analysis, Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran

Source: Science of the Total Environment Published:2022

Abstract

Exposure to airborne particulate matter (PM) can be considered as an important risk factor for human health. Some cytokines have been recognized as the biomarkers of exposure to air pollution. Experimental studies indicate that PM exposure could be associated with inflammation. Thus, the purpose of this study was to evaluate whether the exposure to air PM is associated with biomarkers of inflammation. The specific aim of this study was to determine the correlation between airborne PM levels and IL-6 and TNF-α as airway inflammation biomarkers among two groups of late adolescents in northwest of Iran. This study included 46 subjects, comprising 23 asthmatic subjects and 23 non-asthmatic persons. Environmental PM (PM10, PM2.5 and PM1) levels were measured in dust storm and non-dust storm days during both cold and warm seasons. Following the sampling of PM, Two pro-inflammatory cytokines of IL-6 and TNF-α in exhaled breath condensate (EBC) were also determined in the EBC samples via commercial ELISA kits. Daily mean ambient air PM10, PM2.5 and PM1 concentrations during the dust storm days was 221.79, 93.13 and 25.52 μg m−3 and in non-dusty days 48.37, 18.54 and 6.1 μg m−3, respectively. Biomarkers levels were significantly (p < 0.001) higher in asthmatic students compared to the non-asthmatic subjects. EBC cytokines levels were increased in dust storm days compared to the non-dusty days (p < 0.001) and were positively correlated with different size of ambient PM concentration. Dust storm conditions can increase the pro-inflammatory cytokines and cause adverse effects on pulmonary health and lung tissue damage. © 2022

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Style	Citing Format
MLA	Ghozikali MG, et al.. "Status of Tnf-Α and Il-6 As Pro-Inflammatory Cytokines in Exhaled Breath Condensate of Late Adolescents With Asthma and Healthy in the Dust Storm and Non-Dust Storm Conditions." Science of the Total Environment, vol. 838, no. , 2022, pp. -.
APA	Ghozikali MG, Ansarin K, Naddafi K, Nabizadeh R, Yaghmaeian K, Jaafari J, Dehghanzadeh R, Atafar Z, Faraji M, Mohammadi A, Goudarzi G, Yunesian M (2022). Status of Tnf-Α and Il-6 As Pro-Inflammatory Cytokines in Exhaled Breath Condensate of Late Adolescents With Asthma and Healthy in the Dust Storm and Non-Dust Storm Conditions. Science of the Total Environment, 838(), -.
Chicago	Ghozikali MG, Ansarin K, Naddafi K, Nabizadeh R, Yaghmaeian K, Jaafari J, Dehghanzadeh R, et al.. "Status of Tnf-Α and Il-6 As Pro-Inflammatory Cytokines in Exhaled Breath Condensate of Late Adolescents With Asthma and Healthy in the Dust Storm and Non-Dust Storm Conditions." Science of the Total Environment 838, no. (2022): -.
Harvard	Ghozikali MG et al. (2022) 'Status of Tnf-Α and Il-6 As Pro-Inflammatory Cytokines in Exhaled Breath Condensate of Late Adolescents With Asthma and Healthy in the Dust Storm and Non-Dust Storm Conditions', Science of the Total Environment, 838(), pp. -.
Vancouver	Ghozikali MG, Ansarin K, Naddafi K, Nabizadeh R, Yaghmaeian K, Jaafari J, et al.. Status of Tnf-Α and Il-6 As Pro-Inflammatory Cytokines in Exhaled Breath Condensate of Late Adolescents With Asthma and Healthy in the Dust Storm and Non-Dust Storm Conditions. Science of the Total Environment. 2022;838():-.
BibTex	@article{ author = {Ghozikali MG and Ansarin K and Naddafi K and Nabizadeh R and Yaghmaeian K and Jaafari J and Dehghanzadeh R and Atafar Z and Faraji M and Mohammadi A and Goudarzi G and Yunesian M}, title = {Status of Tnf-Α and Il-6 As Pro-Inflammatory Cytokines in Exhaled Breath Condensate of Late Adolescents With Asthma and Healthy in the Dust Storm and Non-Dust Storm Conditions}, journal = {Science of the Total Environment}, volume = {838}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Ghozikali MG AU - Ansarin K AU - Naddafi K AU - Nabizadeh R AU - Yaghmaeian K AU - Jaafari J AU - Dehghanzadeh R AU - Atafar Z AU - Faraji M AU - Mohammadi A AU - Goudarzi G AU - Yunesian M TI - Status of Tnf-Α and Il-6 As Pro-Inflammatory Cytokines in Exhaled Breath Condensate of Late Adolescents With Asthma and Healthy in the Dust Storm and Non-Dust Storm Conditions JO - Science of the Total Environment VL - 838 IS - SP - EP - PY - 2022 ER -

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