Effect of Ambient Air Pm2.5-Bound Heavy Metals on Blood Metal(Loid)S and Children's Asthma and Allergy Pro-Inflammatory (Ige, Il-4 and Il-13) Biomarkers

Effect of Ambient Air Pm2.5-Bound Heavy Metals on Blood Metal(Loid)S and Children's Asthma and Allergy Pro-Inflammatory (Ige, Il-4 and Il-13) Biomarkers Publisher Pubmed

Zahedi A¹ ; Hassanvand MS² ; Jaafarzadeh N^{3, 4} ; Ghadiri A^{5, 7} ; Shamsipour M⁶ ; Dehcheshmeh MG^{5, 7}

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1. Student Research Committee, Department of Environmental Health Engineering, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2. Centre for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran
3. Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 61355-179, Iran
4. Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5. Department of Immunology, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6. Department of Research Methodology and Data Analysis, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Immunology, Medical School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Journal of Trace Elements in Medicine and Biology Published:2021

Abstract

Background: We investigated the concentrations of metals in fine particulate matter PM2.5 in the outdoor air around the home sites of 123 male children from Ahvaz, average age 7.56, along with their blood samples to measure pro-inflammatory responses (Immunoglobulin E and cytokines: IgE, IL-4 and IL-13). Methods: We measured 6 metals (As, Cd, Cr, Hg, Ni and Pb) in three Ahvaz's regions including industrial (Padad), vehicle traffic (Golestan) and control (Kianpars). Results: The higher concentrations of metals in the Padad as the industrial ambient air i.e., arsenic, cadmium, chromium, mercury and nickel coincided with the higher concentrations of those metals in exposed children (P < 0.05) versus the controls. Children in Golestan, the high traffic air pollution area had the highest lead concentrations (p < 0.05). Also a significant association was shown in Padad between blood arsenic and IgE (β = 26.59, P < 0.001), IL-4 (β = 172.1, P < 0.001) and IL-13 (β = 14.84, P < 0.001), blood chromium and IgE (β = 10.38, P < 0.001), IL-4 (β = 75.27, P < 0.001) and IL-13 (β = 5.27, P < 0.001) and blood mercury and IgE (β = 13.11, P < 0.001), IL-4 (β = 108.09, P < 0.001) and IL-13 (β = 7.96, P < 0.001) and blood lead and IgE(β = 0.92, P = 0.025), IL-4(β = 7.16, P < 0.001) and IL-13(β = 0.58, P = 0.003). However, no significant relation was found for Cadmium, Nickel in blood with IgE, IL-4 and IL-13 levels. Moreover, children from industrial areas showed significantly higher concentrations of IgE (mean = 146.44 pg/200landa, P < 0.001), IL-4 (mean = 548.23 pg/200landa, P < 0.001) and IL-13 (mean = 52.93 pg/200landa, P < 0.001) versus Golestan and Kianpars. Conclusion: Children residing in an industrial area with high concentrations of metals in PM2.5 had high metals in blood and high production of IgE, IL-4 and IL-13, reflecting an immune dysregulation and brisk inflammatory responses. © 2021 Elsevier GmbH

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Style	Citing Format
MLA	Zahedi A, et al.. "Effect of Ambient Air Pm2.5-Bound Heavy Metals on Blood Metal(Loid)S and Children's Asthma and Allergy Pro-Inflammatory (Ige, Il-4 and Il-13) Biomarkers." Journal of Trace Elements in Medicine and Biology, vol. 68, no. , 2021, pp. -.
APA	Zahedi A, Hassanvand MS, Jaafarzadeh N, Ghadiri A, Shamsipour M, Dehcheshmeh MG (2021). Effect of Ambient Air Pm2.5-Bound Heavy Metals on Blood Metal(Loid)S and Children's Asthma and Allergy Pro-Inflammatory (Ige, Il-4 and Il-13) Biomarkers. Journal of Trace Elements in Medicine and Biology, 68(), -.
Chicago	Zahedi A, Hassanvand MS, Jaafarzadeh N, Ghadiri A, Shamsipour M, Dehcheshmeh MG. "Effect of Ambient Air Pm2.5-Bound Heavy Metals on Blood Metal(Loid)S and Children's Asthma and Allergy Pro-Inflammatory (Ige, Il-4 and Il-13) Biomarkers." Journal of Trace Elements in Medicine and Biology 68, no. (2021): -.
Harvard	Zahedi A et al. (2021) 'Effect of Ambient Air Pm2.5-Bound Heavy Metals on Blood Metal(Loid)S and Children's Asthma and Allergy Pro-Inflammatory (Ige, Il-4 and Il-13) Biomarkers', Journal of Trace Elements in Medicine and Biology, 68(), pp. -.
Vancouver	Zahedi A, Hassanvand MS, Jaafarzadeh N, Ghadiri A, Shamsipour M, Dehcheshmeh MG. Effect of Ambient Air Pm2.5-Bound Heavy Metals on Blood Metal(Loid)S and Children's Asthma and Allergy Pro-Inflammatory (Ige, Il-4 and Il-13) Biomarkers. Journal of Trace Elements in Medicine and Biology. 2021;68():-.
BibTex	@article{ author = {Zahedi A and Hassanvand MS and Jaafarzadeh N and Ghadiri A and Shamsipour M and Dehcheshmeh MG}, title = {Effect of Ambient Air Pm2.5-Bound Heavy Metals on Blood Metal(Loid)S and Children's Asthma and Allergy Pro-Inflammatory (Ige, Il-4 and Il-13) Biomarkers}, journal = {Journal of Trace Elements in Medicine and Biology}, volume = {68}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Zahedi A AU - Hassanvand MS AU - Jaafarzadeh N AU - Ghadiri A AU - Shamsipour M AU - Dehcheshmeh MG TI - Effect of Ambient Air Pm2.5-Bound Heavy Metals on Blood Metal(Loid)S and Children's Asthma and Allergy Pro-Inflammatory (Ige, Il-4 and Il-13) Biomarkers JO - Journal of Trace Elements in Medicine and Biology VL - 68 IS - SP - EP - PY - 2021 ER -

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