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Proinflammatory Effects of Dust Storm and Thermal Inversion Particulate Matter (Pm10) on Human Peripheral Blood Mononuclear Cells (Pbmcs) in Vitro: A Comparative Approach and Analysis Publisher



Atafar Z1 ; Pourpak Z2 ; Yunesian M1, 3 ; Nicknam MH4, 5 ; Hassanvand MS6 ; Soleimanifar N4 ; Saghafi S2 ; Alizadeh Z2 ; Rezaei S1 ; Ghanbarian M1 ; Ghozikali MG7 ; Osorniovargas AR8 ; Naddafi K1, 6
Authors
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Authors Affiliations
  1. 1. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Research Methodology and Data Analysis Department, Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Health and Environment Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Department of Pediatrics, University of Alberta, Edmonton, Canada

Source: Journal of Environmental Health Science and Engineering Published:2019


Abstract

Particulate matter (PM) as the carcinogenic air pollutants can lead to aggravated health outcomes. Epidemiological studies demonstrated that PM can be engaged in different diseases such as cardiovascular, respiratory and cancer. The in vitro secretion of proinflammatory cytokines by human peripheral blood mononuclear cells (PBMCs) has been used to assess the effects of PM with an aerodynamic diameter < 10 μm (PM10). This study compared the proinflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1-beta (IL1-β) secretions of PBMCs exposed to PM10 of dust storm and inversion. We collected PM10 samples during the spring and autumn seasons in two locations. Isolated PBMCs were exposed separately to 50, 150, and 300 μg/ml of different type of PM10 for 4 and 24 h. The mean concentrations of TNF-α for the PM of dust storm and inversion were 6305.61 ± 2421 and 6651.74 ± 2820, respectively. Also the mean concentrations of IL1-β for the PM of dust storm and inversion were 556.86 ± 162 and 656.35 ± 196, respectively. Furthermore, these values for the production of IL-6 were 12,655 ± 5661 and 16,685 ± 8069, respectively. Although no significant difference was observed between the PM of dust storm and that of inversion with regard to PBMCs, the results showed a significant increase in the proinflammatory cytokine secretion of both PMs compared with the controls. Moreover, TNF-α, IL1-β, and IL-6 secreted in cells exposed to PM10 of dust storm were about 10 times more than the controls, these values for cells exposed to PM10 of inversion were around 10, 12, and 14 times more than the controls, respectively. It can be concluded that the PM10 of both dust storm and inversion can play a significant role in proinflammatory cytokine secretion due to its harmful effect on human health. [Figure not available: see fulltext.] © 2019 Springer Nature Switzerland AG.
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