Up-Regulation of Fto Gene Expression Was Associated With Increase in Skeletal Muscle Mass in Overweight Male Adolescents

Up-Regulation of Fto Gene Expression Was Associated With Increase in Skeletal Muscle Mass in Overweight Male Adolescents Publisher

Doaei S^{1, 2} ; Kalantari N³ ; Mohammadi NK⁴ ; Izadi P⁵ ; Gholamalizadeh M² ; Einizinab H³ ; Salonurmi T⁶ ; Jarrahi AM² ; Rafieifar S⁷ ; Janipoor R⁸ ; Sadeghypor M⁹ ; Tabesh GA⁵ ; Goodarzi MO¹⁰

Show Affiliations

1. Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran
2. Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Internal Medicine, Oulu University Hospital, University of Oulu, Oulu, Finland
7. Health Promotion and Education Department, Ministry of Health, Tehran, Iran
8. Department of Veterinary Medicine, School of Veterinary Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
9. Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran
10. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Source: Archives of Medical Science Published:2019

Abstract

Introduction: The modifying effect of FTO gene expression level on change in body mass index and body composition has not been studied before. This study aimed to investigate the association between change in the expression level of the FTO gene and changes in anthropometric measurements in obese and overweight adolescent boys. Material and methods: Eighty-four boys aged 12 to 16 years participated in this longitudinal study. A Bio Impedance Analyzer (BIA) was used to estimate percentage of body fat (%BF) and percentage of skeletal muscle (%SM). The FTO gene expression level in peripheral blood mononuclear cells was assessed using quantitative real-time PCR (qPCR). All measurements were performed at baseline and after 18 weeks. Results: After 18 weeks, mean weight was reduced by 2.39 kg, body mass index by 0.09 kg/m2, %BF by 0.82% and %SM increased by 0.44%. Moreover, the level of FTO gene expression increased 0.42-fold higher than baseline. The change in expression level of the FTO gene was positively associated with change in %SM (β = 0.31, p = 0.02). Conclusions: FTO gene expression change was associated with change in %SM in male adolescents. Future studies are required to assess the interactions between FTO gene expression in different tissues and body composition. Copyright © 2019 Termedia & Banach

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Pantea Izadi (5)

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Style	Citing Format
MLA	Doaei S, et al.. "Up-Regulation of Fto Gene Expression Was Associated With Increase in Skeletal Muscle Mass in Overweight Male Adolescents." Archives of Medical Science, vol. 15, no. 5, 2019, pp. 1133-1137.
APA	Doaei S, Kalantari N, Mohammadi NK, Izadi P, Gholamalizadeh M, Einizinab H, Salonurmi T, Jarrahi AM, Rafieifar S, Janipoor R, Sadeghypor M, Tabesh GA, Goodarzi MO (2019). Up-Regulation of Fto Gene Expression Was Associated With Increase in Skeletal Muscle Mass in Overweight Male Adolescents. Archives of Medical Science, 15(5), 1133-1137.
Chicago	Doaei S, Kalantari N, Mohammadi NK, Izadi P, Gholamalizadeh M, Einizinab H, Salonurmi T, et al.. "Up-Regulation of Fto Gene Expression Was Associated With Increase in Skeletal Muscle Mass in Overweight Male Adolescents." Archives of Medical Science 15, no. 5 (2019): 1133-1137.
Harvard	Doaei S et al. (2019) 'Up-Regulation of Fto Gene Expression Was Associated With Increase in Skeletal Muscle Mass in Overweight Male Adolescents', Archives of Medical Science, 15(5), pp. 1133-1137.
Vancouver	Doaei S, Kalantari N, Mohammadi NK, Izadi P, Gholamalizadeh M, Einizinab H, et al.. Up-Regulation of Fto Gene Expression Was Associated With Increase in Skeletal Muscle Mass in Overweight Male Adolescents. Archives of Medical Science. 2019;15(5):1133-1137.
BibTex	@article{ author = {Doaei S and Kalantari N and Mohammadi NK and Izadi P and Gholamalizadeh M and Einizinab H and Salonurmi T and Jarrahi AM and Rafieifar S and Janipoor R and Sadeghypor M and Tabesh GA and Goodarzi MO}, title = {Up-Regulation of Fto Gene Expression Was Associated With Increase in Skeletal Muscle Mass in Overweight Male Adolescents}, journal = {Archives of Medical Science}, volume = {15}, number = {5}, pages = {1133-1137}, year = {2019} }
RIS	TY - JOUR AU - Doaei S AU - Kalantari N AU - Mohammadi NK AU - Izadi P AU - Gholamalizadeh M AU - Einizinab H AU - Salonurmi T AU - Jarrahi AM AU - Rafieifar S AU - Janipoor R AU - Sadeghypor M AU - Tabesh GA AU - Goodarzi MO TI - Up-Regulation of Fto Gene Expression Was Associated With Increase in Skeletal Muscle Mass in Overweight Male Adolescents JO - Archives of Medical Science VL - 15 IS - 5 SP - 1133 EP - 1137 PY - 2019 ER -

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