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The Role of Fto Genotype in the Association Between Fto Gene Expression and Anthropometric Measures in Obese and Overweight Adolescent Boys Publisher Pubmed



Doaei S1, 2, 3 ; Kalantari N4 ; Keshavarz Mohammadi N5 ; Izadi P6 ; Gholamalizadeh M3 ; Einizinab H4 ; Salonurmi T7 ; Mosavi Jarrahi A3 ; Rafieifar S8 ; Najafi R9 ; Sadeghypor M10 ; Azizi Tabesh G11 ; Goodarzi MO12
Authors
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Authors Affiliations
  1. 1. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
  2. 2. Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran
  3. 3. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Public Health, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Internal Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland
  8. 8. Health Promotion and Education Department, Ministry of Health, Tehran, Iran
  9. 9. Deputy of Education and Training of Naja, Tehran, Iran
  10. 10. Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  11. 11. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Source: American Journal of Men's Health Published:2019


Abstract

The role of FTO genotype in the effect of FTO gene expression level on change in body mass index and body composition has not been studied. This study aimed to investigate the role of FTO genotype in the association between change in the expression level of the FTO gene with changes in anthropometric measurements in obese and overweight adolescent boys. Eighty-four boys aged 12 to 16 years participated in this longitudinal study. A bioimpedance analyzer (BIA) was used to estimate percentage of body fat (%body fat) and percentage of skeletal muscle (%skeletal muscle). The FTO gene expression level in peripheral blood mononuclear cells (PBMCs) was assessed using quantitative Real Time PCR (qPCR). The DNA samples were genotyped for the FTO gene polymorphisms by DNA sequencing. All measurements were performed at baseline and after intervention. A significant association was observed between the level of gene expression and %skeletal muscle. The gene expression fold change was significantly associated with change in %skeletal muscle in AA or AG genotype carriers (β = 0.34, p =.02). No significant association was detected between the change in FTO gene expression with change in anthropometric indices in GG genotype carriers. In conclusion, the association between FTO gene expression and body composition can be influenced by FTO genotype. Future studies are required to assess the interactions between FTO genotype, FTO gene expression in different tissues, and body composition. © The Author(s) 2019.
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