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Changes in Fto and Irx3 Gene Expression in Obese and Overweight Male Adolescents Undergoing an Intensive Lifestyle Intervention and the Role of Fto Genotype in This Interaction Publisher Pubmed



Doaei S1, 2 ; Kalantari N3 ; Izadi P4 ; Salonurmi T5 ; Mosavi Jarrahi A6 ; Rafieifar S7 ; Azizi Tabesh G8 ; Rahimzadeh G9 ; Gholamalizadeh M10 ; Goodarzi MO11
Authors
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Authors Affiliations
  1. 1. Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran
  2. 2. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Internal Medicine, Oulu University Hospital, University of Oulu, Oulu, Finland
  6. 6. Faculty of Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Health Promotion and Education Department, Ministry of Health, Tehran, Iran
  8. 8. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Institute for Intelligent Systems Research and Innovation (IISRI), Deakin University, Geelong Waurn Ponds, Australia
  10. 10. Stud. Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Source: Journal of Translational Medicine Published:2019


Abstract

Background: Lifestyle intervention may have a critical effect on the association between genetics and obesity. This study aimed to investigate changes in FTO and IRX3 gene expression in obese and overweight male adolescents undergoing a lifestyle intervention and the role of FTO genotype in this interaction. Methods: This study was a field trial of 62 adolescents from boys' high schools in Tehran, Iran. Two schools were randomly allocated as the intervention (n = 30) and control (n = 32) schools. The rs9930506 SNP in FTO was genotyped at baseline and the level of FTO and IRX3 expression in peripheral blood mononuclear cells (PBMCs). Anthropometric measurements were assessed at baseline and after 18 weeks of intensive lifestyle intervention. Results: Our results showed that IRX3 expression in the intervention group was significantly up-regulated compared to baseline (P = 0.007) and compared to the control group (P = 0.011).The intervention group had significantly up-regulated transcripts of IRX3 only in rs9930506 risk allele carriers of the intervention group compared to risk allele carriers of the control group (P = 0.017). Moreover, our data showed that the FTO expression was up-regulated in AA genotype carriers and down-regulated in AG/GG genotype carriers (P = 0.017). Conclusion: Lifestyle modification may exert its effects on obesity through changes in the expression level of the FTO and IRX3 genes. However, FTO genotype plays a role in the extent of the effect of lifestyle changes on gene expression. Further studies are crucial to have a better understanding of the interaction between lifestyle, genetics and anthropometric measurements. © 2019 The Author(s).
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