A Complete Linkage Disequilibrium in a Haplotype of Three Snps in Fat Mass and Obesity Associated (Fto) Gene Was Strongly Associated With Anthropometric Indices After Controlling for Calorie Intake and Physical Activity

A Complete Linkage Disequilibrium in a Haplotype of Three Snps in Fat Mass and Obesity Associated (Fto) Gene Was Strongly Associated With Anthropometric Indices After Controlling for Calorie Intake and Physical Activity Publisher Pubmed

Kalantari N¹ ; Keshavarz Mohammadi N² ; Izadi P³ ; Gholamalizadeh M⁴ ; Doaei S^{5, 6, 7} ; Einizinab H¹ ; Salonurmi T⁸ ; Rafieifar S⁹ ; Janipoor R¹⁰ ; Azizi Tabesh G¹¹

Show Affiliations

1. Shahid Beheshti University of Medical Sciences, Department of community nutrition, School of Nutrition and Food Sciences, Tehran, Iran
2. Shahid Beheshti University of Medical Sciences, Department of public health, Tehran, Iran
3. Tehran University of Medical Sciences, Department of Medical Genetics, School of Medicine, Tehran, Iran
4. Shahid Beheshti University of Medical Sciences, Student Research Committee, Cancer Research Center, Tehran, Iran
5. North Khorasan University of Medical Sciences, Natural Products and Medicinal Plants Research Center, Bojnurd, Iran
6. North Khorasan University of Medical Sciences, Department of public health, School of Public Health, Bojnurd, Iran
7. Shahid Beheshti University of Medical Sciences, Cancer Research Center, Tehran, Iran
8. University of Oulu, Research groups of Internal Medicine, Faculty of Medicine, Oulu, Finland
9. Ministry of health, Health Promotion and Education Department, Tehran, Iran
10. Shiraz University of medical sciences, Department of Veterinary Medicine, School of Veterinary Medicine, Shiraz, Iran
11. Tehran University of Medical Sciences, Department of Medical Genetics, Faculty of Human Genetics, Tehran, Iran

Source: BMC Medical Genetics Published:2018

Abstract

Background: The underlying mechanism of the effect of FTO genotype on body mass index (BMI) and body composition is unknown. The objective of the study was to investigate the association of FTO gene polymorphisms with anthropometric indices in adolescent boys after adjustments for dietary intake and physical activity. Methods: In this school-based study, we enrolled 123 male adolescents without extra weight and 110 male adolescents with body mass index (BMI) higher than +1 Z-score. The DNA samples were genotyped for the FTO gene polymorphisms by DNA Sequencing. BMI and body composition were assessed using bioelectrical impedance analyzer scale. Association of the FTO polymorphisms with Weight, height, BMI, body fat percent and skeletal muscle percent were investigated. Data on potential confounders (calorie intake and physical activity) were collected through the use of pre-tested questionnaires. Results: Adolescents with higher BMI and body fat percent and lower skeletal muscle percent were more likely to have a newly found haplotype of rs9930506, rs9930501 & rs9932754 (GGT) in the first intron of the FTO with complete linkage disequilibrium (LD) compared with those with the lower BMI (6.15;2.28-16.63), body fat percent (9.54;0.92-47.44) and higher skeletal muscle percent (9.26;1.85-46.38). This association was not changed after controlling for age. Additional adjustments for calorie intake and physical activity did not alter the association. Conclusions: A haplotype in the first intron of the FTO gene had a strong association with obesity indices in adolescent boys after adjustments for calorie intake and physical activity. It's suggested that the FTO genotype exert its effects on adolescents' anthropometric indices as haplotype and through mechanisms other than changes in calorie intake and expenditure. © 2018 The Author(s).

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Pantea Izadi (3)

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Style	Citing Format
MLA	Kalantari N, et al.. "A Complete Linkage Disequilibrium in a Haplotype of Three Snps in Fat Mass and Obesity Associated (Fto) Gene Was Strongly Associated With Anthropometric Indices After Controlling for Calorie Intake and Physical Activity." BMC Medical Genetics, vol. 19, no. 1, 2018, pp. -.
APA	Kalantari N, Keshavarz Mohammadi N, Izadi P, Gholamalizadeh M, Doaei S, Einizinab H, Salonurmi T, Rafieifar S, Janipoor R, Azizi Tabesh G (2018). A Complete Linkage Disequilibrium in a Haplotype of Three Snps in Fat Mass and Obesity Associated (Fto) Gene Was Strongly Associated With Anthropometric Indices After Controlling for Calorie Intake and Physical Activity. BMC Medical Genetics, 19(1), -.
Chicago	Kalantari N, Keshavarz Mohammadi N, Izadi P, Gholamalizadeh M, Doaei S, Einizinab H, Salonurmi T, Rafieifar S, Janipoor R, Azizi Tabesh G. "A Complete Linkage Disequilibrium in a Haplotype of Three Snps in Fat Mass and Obesity Associated (Fto) Gene Was Strongly Associated With Anthropometric Indices After Controlling for Calorie Intake and Physical Activity." BMC Medical Genetics 19, no. 1 (2018): -.
Harvard	Kalantari N et al. (2018) 'A Complete Linkage Disequilibrium in a Haplotype of Three Snps in Fat Mass and Obesity Associated (Fto) Gene Was Strongly Associated With Anthropometric Indices After Controlling for Calorie Intake and Physical Activity', BMC Medical Genetics, 19(1), pp. -.
Vancouver	Kalantari N, Keshavarz Mohammadi N, Izadi P, Gholamalizadeh M, Doaei S, Einizinab H, et al.. A Complete Linkage Disequilibrium in a Haplotype of Three Snps in Fat Mass and Obesity Associated (Fto) Gene Was Strongly Associated With Anthropometric Indices After Controlling for Calorie Intake and Physical Activity. BMC Medical Genetics. 2018;19(1):-.
BibTex	@article{ author = {Kalantari N and Keshavarz Mohammadi N and Izadi P and Gholamalizadeh M and Doaei S and Einizinab H and Salonurmi T and Rafieifar S and Janipoor R and Azizi Tabesh G}, title = {A Complete Linkage Disequilibrium in a Haplotype of Three Snps in Fat Mass and Obesity Associated (Fto) Gene Was Strongly Associated With Anthropometric Indices After Controlling for Calorie Intake and Physical Activity}, journal = {BMC Medical Genetics}, volume = {19}, number = {1}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Kalantari N AU - Keshavarz Mohammadi N AU - Izadi P AU - Gholamalizadeh M AU - Doaei S AU - Einizinab H AU - Salonurmi T AU - Rafieifar S AU - Janipoor R AU - Azizi Tabesh G TI - A Complete Linkage Disequilibrium in a Haplotype of Three Snps in Fat Mass and Obesity Associated (Fto) Gene Was Strongly Associated With Anthropometric Indices After Controlling for Calorie Intake and Physical Activity JO - BMC Medical Genetics VL - 19 IS - 1 SP - EP - PY - 2018 ER -

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