Human Leukocyte Antigen Class I (A, B) and Class Ii (Drb1) Allele and Haplotype Frequencies in Iranian Patients With Buerger's Disease

Human Leukocyte Antigen Class I (A, B) and Class Ii (Drb1) Allele and Haplotype Frequencies in Iranian Patients With Buerger's Disease Publisher Pubmed

Dehghani Firouzabadi F^{1, 2, 3, 4} ; Salimi J¹ ; Amirzargar A² ; Dehghani Firouzabadi M^{1, 2, 3} ; Arbabi H⁵ ; Mousavizadeh SM⁶ ; Izadpanah K¹

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1. Department of Vascular Surgery, Sina Hospital, Tehran University of Medical Science, Tehran, Iran
2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. ENT and Head and Neck Research Center and Department, Five Senses Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
4. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Project Management Department, Tarbiat Modares University, Tehran, Iran
6. Department of Plastic Surgery, 15 Khordad Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Immunity# Inflammation and Disease Published:2020

Abstract

Objective: The aim of this study was to investigate the human leukocyte antigen (HLA) class I (HLA-A and HLA-B) and II (HLA-DRB1) allele and haplotype frequencies in a group of Iranian patients with Buerger's disease (BD) in comparison with a normal healthy control group. Methods: A total of 70 unrelated male patients and 100 healthy controls from Sina Hospital, Tehran, Iran, belonging to the same ethnic background, were enrolled in this case-control study. HLA-A, B, and DRB1 typing were performed by polymerase chain reaction with sequence-specific primers (PCR-SSP). Results: The results of this case-control study showed that the frequency of the HLA-A*03:01 (odds ratio (OR) = 2.88, P value (Pv) =.002), HLA-A*29:01 (OR = 15.31, Pv <.001), HLA-DRB1*04:02 (OR = 3.41, Pv <.001), and HLA-DRB1*16:01 (OR = 8.16, Pv <.001) was significantly higher in BD patients compared with healthy controls, whereas the frequency of the HLA-DRB1*01:01 (OR = 0.03, Pv <.001) was significantly lower in BD patients. The most frequent extended haplotypes in our patients were HLA-A*02:01-B*55:01-DRB1*04:03. Conclusion: This study is the first study evaluating an association between the HLA pattern and BD in the patients with BD from North West and North Iran. © 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd

Style	Citing Format
MLA	Dehghani Firouzabadi F, et al.. "Human Leukocyte Antigen Class I (A, B) and Class Ii (Drb1) Allele and Haplotype Frequencies in Iranian Patients With Buerger's Disease." Immunity# Inflammation and Disease, vol. 8, no. 3, 2020, pp. 434-440.
APA	Dehghani Firouzabadi F, Salimi J, Amirzargar A, Dehghani Firouzabadi M, Arbabi H, Mousavizadeh SM, Izadpanah K (2020). Human Leukocyte Antigen Class I (A, B) and Class Ii (Drb1) Allele and Haplotype Frequencies in Iranian Patients With Buerger's Disease. Immunity# Inflammation and Disease, 8(3), 434-440.
Chicago	Dehghani Firouzabadi F, Salimi J, Amirzargar A, Dehghani Firouzabadi M, Arbabi H, Mousavizadeh SM, Izadpanah K. "Human Leukocyte Antigen Class I (A, B) and Class Ii (Drb1) Allele and Haplotype Frequencies in Iranian Patients With Buerger's Disease." Immunity# Inflammation and Disease 8, no. 3 (2020): 434-440.
Harvard	Dehghani Firouzabadi F et al. (2020) 'Human Leukocyte Antigen Class I (A, B) and Class Ii (Drb1) Allele and Haplotype Frequencies in Iranian Patients With Buerger's Disease', Immunity# Inflammation and Disease, 8(3), pp. 434-440.
Vancouver	Dehghani Firouzabadi F, Salimi J, Amirzargar A, Dehghani Firouzabadi M, Arbabi H, Mousavizadeh SM, et al.. Human Leukocyte Antigen Class I (A, B) and Class Ii (Drb1) Allele and Haplotype Frequencies in Iranian Patients With Buerger's Disease. Immunity# Inflammation and Disease. 2020;8(3):434-440.
BibTex	@article{ author = {Dehghani Firouzabadi F and Salimi J and Amirzargar A and Dehghani Firouzabadi M and Arbabi H and Mousavizadeh SM and Izadpanah K}, title = {Human Leukocyte Antigen Class I (A, B) and Class Ii (Drb1) Allele and Haplotype Frequencies in Iranian Patients With Buerger's Disease}, journal = {Immunity# Inflammation and Disease}, volume = {8}, number = {3}, pages = {434-440}, year = {2020} }
RIS	TY - JOUR AU - Dehghani Firouzabadi F AU - Salimi J AU - Amirzargar A AU - Dehghani Firouzabadi M AU - Arbabi H AU - Mousavizadeh SM AU - Izadpanah K TI - Human Leukocyte Antigen Class I (A, B) and Class Ii (Drb1) Allele and Haplotype Frequencies in Iranian Patients With Buerger's Disease JO - Immunity# Inflammation and Disease VL - 8 IS - 3 SP - 434 EP - 440 PY - 2020 ER -

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