Hla Alleles and Haplotype Frequencies in Iranian Population

Hla Alleles and Haplotype Frequencies in Iranian Population Publisher Pubmed

Ghafourifard S¹ ; Hussen BM^{1, 2, 3} ; Pashmforoush S⁴ ; Akbari MT⁵ ; Arsangjang S⁶ ; Nazer N⁷ ; Hamidieh AA⁸ ; Hajifathali A⁹ ; Dinger ME¹⁰ ; Sayad A^{1, 11} ; Dehaghi MO^{12, 13}

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1. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq
3. Center of Research and Strategic Studies, Lebanese French University, Erbil, Kurdistan Region, Iraq
4. Department of Biological Sciences, Kharazmi University, Karaj, Iran
5. Tehran Medical Genetics Laboratory, Tehran, Iran
6. Department of Biostatistics and Epidemiology, Cancer Gene Therapy Research Center, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
7. Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran
8. Pediatric Cell Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran
9. Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
10. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
11. Dental Research Center, Research Institute for Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
12. Cell Therapy and Hematopoietic Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
13. Hematology, Oncology, and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Human Antibodies Published:2022

Abstract

BACKGROUND: HLA genotyping is a prerequisite for selection of suitable donors in the process of bone marrow transplantation. METHODS: In the current study, the frequencies of HLA-A, -B, -C and -DRB1 alleles and A-B-C-DRB1 haplotypes were assessed in 855 healthy Iranian persons using a low-resolution sequence specific primer (SSP) kit. RESULTS: Frequencies were compared between 11 subpopulations including Armani, Balouch, Bandari, Turk, Turkaman, Arab, Fars, Kurd, Gilaki, Lor and Mazani. In total, 17 HLA-A alleles were detected, one of which (HLA-A*74) was present only among Lors. HLA-A*23 and -A*26 were the most frequent HLA-A alleles among Armanis. HLA-A*23 was also common among Turkamans. HLA-A*11 and -A*26 were most frequent among the Balouch subpopulation. The former allele was also frequent among Bandaris. HLA-A*02 was identified as the most common HLA-A allele among Turk, Arab and Fars subpopulations. HLA-A*30 were strongly enriched among Gilakis. A total of 31 HLA-B alleles were detected across the target population. While all alleles were present among Fars subgroup, Armanis and Turkamans had the lowest degree of diversity among the alleles examined. Moreover, HLA-B*35 and B*49 alleles were strongly enriched among Armanis and Turkamans, respectively. A total of 13 HLA-C alleles were identified across the population, all of which were present in the Fars subpopulation. HLA-C*03 and C*04 were the only HLA-C alleles identified among the Bandari subpopulation. HLA-DRB1*08 was not detected in any subpopulation other than Fars. HLA-DRB1*16 was significantly enriched among Bandaris. These data have practical significance in anthropological studies, disease association investigations and bone marrow transplantation. © 2022 - IOS Press. All rights reserved.

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Style	Citing Format
MLA	Ghafourifard S, et al.. "Hla Alleles and Haplotype Frequencies in Iranian Population." Human Antibodies, vol. 30, no. 2, 2022, pp. 79-96.
APA	Ghafourifard S, Hussen BM, Pashmforoush S, Akbari MT, Arsangjang S, Nazer N, Hamidieh AA, Hajifathali A, Dinger ME, Sayad A, Dehaghi MO (2022). Hla Alleles and Haplotype Frequencies in Iranian Population. Human Antibodies, 30(2), 79-96.
Chicago	Ghafourifard S, Hussen BM, Pashmforoush S, Akbari MT, Arsangjang S, Nazer N, Hamidieh AA, et al.. "Hla Alleles and Haplotype Frequencies in Iranian Population." Human Antibodies 30, no. 2 (2022): 79-96.
Harvard	Ghafourifard S et al. (2022) 'Hla Alleles and Haplotype Frequencies in Iranian Population', Human Antibodies, 30(2), pp. 79-96.
Vancouver	Ghafourifard S, Hussen BM, Pashmforoush S, Akbari MT, Arsangjang S, Nazer N, et al.. Hla Alleles and Haplotype Frequencies in Iranian Population. Human Antibodies. 2022;30(2):79-96.
BibTex	@article{ author = {Ghafourifard S and Hussen BM and Pashmforoush S and Akbari MT and Arsangjang S and Nazer N and Hamidieh AA and Hajifathali A and Dinger ME and Sayad A and Dehaghi MO}, title = {Hla Alleles and Haplotype Frequencies in Iranian Population}, journal = {Human Antibodies}, volume = {30}, number = {2}, pages = {79-96}, year = {2022} }
RIS	TY - JOUR AU - Ghafourifard S AU - Hussen BM AU - Pashmforoush S AU - Akbari MT AU - Arsangjang S AU - Nazer N AU - Hamidieh AA AU - Hajifathali A AU - Dinger ME AU - Sayad A AU - Dehaghi MO TI - Hla Alleles and Haplotype Frequencies in Iranian Population JO - Human Antibodies VL - 30 IS - 2 SP - 79 EP - 96 PY - 2022 ER -

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