Hla-Drb and Hla-Dqb Allele and Haplotype Frequencies in Iranian Patients With Recurrent Aphthous Stomatitis Pubmed



Najafi S¹ ; Mohammadzadeh M² ; Bidoki AZ^{3, 4} ; Meighani G⁵ ; Aslani S^{6, 7} ; Mahmoudi M⁶ ; Rezaei N^{7, 8, 9}
Source: Iranian Journal of Allergy# Asthma and Immunology Published:2016

Abstract

Recurrent aphthous stomatitis (RAS) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. RAS appears to be associated with some human leukocyte antigen (HLA) class II alleles and haplotypes. This study attempts to survey the distribution of HLA-DRB and -DQB alleles among Iranian RAS patients and healthy controls. In order to evaluate the association of HLA-DR and DQ alleles and haplotypes, 54 patients with RAS and 100 unrelated healthy subjects as control group were investigated. Our data indicated that DRB1∗13:17, DRB1∗15:01, and DRB5∗01 were significantly more frequent in RAS patients in comparison to controls. However, DRB3:01allele frequency was higher in the controls compared to the patients. The significantly frequent allele in the patients compared with the healthy subjects was HLA-DQB1∗03:02. However, both HLA-DQB1∗02:01 and HLA-DQB1∗03:01 alleles were most frequent in the healthy individuals rather than the patients. The DRB∗04/DQB1∗03:01 and DRB∗01:01/DQB1∗02:01 haplotypes were significantly distributed in healthy subjects compared with patients. However, DRB∗07:01/DQB1∗03:02 haplotype was found to be significantly frequent in patients than controls. In respect of HLA genes, factors are involved in the incidence of RAS; various HLA-DRB and HLA-DQB1 alleles and the related haplotypes are suggested to be the three main RAS susceptibility factors in our population study. © Summer 2016, Iran J Allergy Asthma Immunol. All rights reserved.