Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Possible Interaction Between the Ventral Hippocampal Cannabinoid Cb2 and Muscarinic Acetylcholine Receptors on the Modulation of Memory Consolidation in Mice Publisher Pubmed



Nasehi M1 ; Forouzanmehr E2 ; Khakpai F1 ; Zarrindast MR3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Iran
  2. 2. Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Iran
  3. 3. Department of Pharmacology, School of Medicine, Iran
  4. 4. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran

Source: NeuroReport Published:2020


Abstract

To clarify possible interaction between the ventral hippocampal cannabinoid CB2 receptors and the cholinergic system in control of the memory process, the effects of cannabinoid and acetylcholine receptor agents on memory consolidation have been investigated in mice. Animals implanted with bilateral cannulas at the CA3 region of the ventral hippocampus and microinjected with scopolamine and cannabinergic agents. These animals were tested using a one-trial step-down inhibitory avoidance task. The results indicated impairment of memory consolidation by posttraining intra-CA3 microinjection of scopolamine (1 and 2 µg/mouse). Nevertheless, coinjection of various doses of scopolamine (0.01, 1 and 2 µg/mouse) with an ineffective dose of AM630 (1 µg/mouse) or GP1a (1 µg/mouse) did not show any significant effect on deficiency of memory consolidation produced by scopolamine. Posttraining application of cannabinoid CB2 receptor antagonist, AM630 (1, 10 and 100 µg/mouse; intra-CA3) alone had no significant influence on memory performance, but its coinjection with significant dose of scopolamine (1 µg/mouse) decreased memory consolidation. Moreover, posttraining injection of GP1a, cannabinoid CB2 receptor agonist, (10 and 100 µg/mouse; intra-CA3) decreased memory consolidation. Posttraining coadministration of diverse doses of GP1a (1, 10 and 100 µg/mouse; intra-CA3) with an effective dose of scopolamine (1 µg/mouse) meaningfully increased deficiency of memory consolidation produced by GP1a (100 µg/mouse). In addition, all drugs had no significant effect on locomotion. Consequently, these results propose that a probable interaction between the CA3 cannabinoid CB2 receptors and muscarinic acetylcholine receptors (mAChR) modulates memory consolidation process in mice. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Related Docs
View other Related Docs
1. Dorsal Hippocampal Cannabinergic and Gabaergic Systems Modulate Memory Consolidation in Passive Avoidance Task, Brain Research Bulletin (2018)
2. The Effect of Ca1 Dopaminergic System on Amnesia Induced by Harmane in Mice, Acta Neurologica Belgica (2019)
3. How Do Stupendous Cannabinoids Modulate Memory Processing Via Affecting Neurotransmitter Systems?, Neuroscience and Biobehavioral Reviews (2021)
4. The Modulatory Role of Dopamine in Anxiety-Like Behavior, Archives of Iranian Medicine (2015)
5. Possible Involvement of the Ca1 Gabaergic System on Harmaline Induced Memory Consolidation Deficit, Brain Research Bulletin (2017)
6. The Modulatory Effect of Ca1 Gabab Receptors on Ketamine-Induced Spatial and Non-Spatial Novelty Detection Deficits With Respect to Ca2+, Neuroscience (2015)
7. The Role of Nmda Receptors of the Medial Septum and Dorsal Hippocampus on Memory Acquisition, Pharmacology Biochemistry and Behavior (2016)
8. Interaction Between Harmane, a Class of Β-Carboline Alkaloids, and the Ca1 Serotonergic System in Modulation of Memory Acquisition, Neuroscience Research (2017)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (1)
Anahita Torkaman-Boutorabi (1)
Other Related Docs
9. Additive Effect of Harmane and Muscimol for Memory Consolidation Impairment in Inhibitory Avoidance Task, Neuroscience (2016)
10. State-Dependent Memory and Its Modulation by Different Brain Areas and Neurotransmitters, EXCLI Journal (2020)
11. Synergistic Effect Between D-Ap5 and Muscimol in the Nucleus Accumbens Shell on Memory Consolidation Deficit in Adult Male Wistar Rats: An Isobologram Analysis, Neurobiology of Learning and Memory (2017)
12. The Modulatory Role of Nicotine on Cognitive and Non-Cognitive Functions, Brain Research (2019)
13. The Effect of Ca1 Dopaminergic System in Harmaline-Induced Amnesia, Neuroscience (2015)
14. The Involvement of Medial Septum 5-Ht1 and 5-Ht2 Receptors on Acpa-Induced Memory Consolidation Deficit: Possible Role of Trpc3, Trpc6 and Trpv2, Journal of Psychopharmacology (2015)
15. Neurotransmission Systems in Parkinson's Disease, Reviews in the Neurosciences (2017)
16. Involvement of Medial Prefrontal Cortex Alpha-2 Adrenoceptors on Memory Acquisition Deficit Induced by Arachidonylcyclopropylamide, a Cannabinoid Cb1 Receptor Agonist, in Rats; Possible Involvement of Ca2+ Channels, Journal of Psychopharmacology (2016)
17. Interplay Between Serotonin and Cannabinoid Function in the Amygdala in Fear Conditioning, Brain Research (2016)
18. Interaction Between Hippocampal Serotonin and Cannabinoid Systems in Reactivity to Spatial and Object Novelty Detection, Behavioural Brain Research (2017)
19. Modulation of Cannabinoid Signaling by Hippocampal 5-Ht4 Serotonergic System in Fear Conditioning, Journal of Psychopharmacology (2016)
20. Interaction Between Nmda and Cb2 Function in the Dorsal Hippocampus on Memory Consolidation Impairment: An Isobologram Analysis, Psychopharmacology (2017)
21. Harmaline Potentiates Morphine-Induced Antinociception Via Affecting the Ventral Hippocampal Gaba-A Receptors in Mice, European Journal of Pharmacology (2021)
22. Synergistic Interaction Between Clonidine and Acpa on the Modulation of Anxiety-Like Behaviors in Non-Acute Restraint Stress and Acute Restraint Stress Conditions, Brain Research (2025)
23. Additive Effect of Bla Gabaa Receptor Mechanism and (+)-Mk-801 on Memory Retention Deficit, an Isobologram Analysis, Pharmacology Biochemistry and Behavior (2016)
24. The Role of 5-Ht4 Serotonin Receptors in the Ca1 Hippocampal Region on Memory Acquisition Impairment Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Physiology and Behavior (2020)
25. Role of the Cannabinoid Cb1 Receptor in Methamphetamine-Induced Social and Recognition Memory Impairment, Neuroscience Letters (2022)
26. Hippocampal Nicotinic Receptors Have a Modulatory Role for Ethanol and Mdma Interaction in Memory Retrieval, Brain Research (2017)
27. Different Role of Ca1 5Ht3 Serotonin Receptors on Memory Acquisition Deficit Induced Total(Tsd) and Rem Sleep Deprivation(Rsd), Archives of Iranian Medicine (2017)
28. Harmaline-Induced Amnesia: Possible Role of the Amygdala Dopaminergic System, Neuroscience (2016)
29. Bidirectional Influence of Amygdala Β1-Adrenoceptors Blockade on Cannabinoid Signaling in Contextual and Auditory Fear Memory, Journal of Psychopharmacology (2018)
30. The Effect of 5-Ht4 Serotonin Receptors in the Ca3 Hippocampal Region on D-Ap5-Induced Anxiolytic-Like Effects: Isobolographic Analyses, Behavioural Brain Research (2021)
31. The Strengths and Limits of Cannabinoids and Their Receptors in Cancer: Insights Into the Role of Tumorigenesis-Underlying Mechanisms and Therapeutic Aspects, Biomedicine and Pharmacotherapy (2021)
32. Modulation of the Effects of the Cannabinoid Agonist, Acpa, on Spatial and Non-Spatial Novelty Detection in Mice by Dopamine D1 Receptor Drugs Infused Into the Basolateral Amygdala, Behavioural Brain Research (2015)
33. The Hippocampal Nmda Receptors May Be Involved in Acquisition, But Not Expression of Acpa-Induced Place Preference, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2015)
34. The Effect of Ca1 Α2 Adrenergic Receptors on Memory Retention Deficit Induced by Total Sleep Deprivation and the Reversal of Circadian Rhythm in a Rat Model, Neurobiology of Learning and Memory (2016)
35. Activation and Inactivation of Nicotinic Receptnors in the Dorsal Hippocampal Region Restored Negative Effects of Total (Tsd) and Rem Sleep Deprivation (Rsd) on Memory Acquisition, Locomotor Activity and Pain Perception, Neuroscience (2020)
36. The Effects of Ca1 5Ht4 Receptors in Mk801-Induced Amnesia and Hyperlocomotion, Neuroscience Letters (2015)
37. Role of Ca1 Gabaa and Gabab Receptors on Learning Deficit Induced by D-Ap5 in Passive Avoidance Step-Through Task, Brain Research (2018)
38. Endo-Cannabinoids System and the Toxicity of Cannabinoids With a Biotechnological Approach, EXCLI Journal (2017)
39. The Interaction Between Hippocampal Gaba-B and Cannabinoid Receptors Upon Spatial Change and Object Novelty Discrimination Memory Function, Psychopharmacology (2017)
40. Urb597 Abrogates Anxiogenic and Depressive Behaviors in the Methamphetamine-Withdrawal Mice: Role of the Cannabinoid Receptor Type 1, Cannabinoid Receptor Type 2, and Transient Receptor Potential Vanilloid 1 Channels, Journal of Psychopharmacology (2021)
41. Novel Object Recognition Memory in Rem Sleep-Deprived Rats: Role of the Cannabinoid Cb1 Receptor, Behavioural Brain Research (2020)
42. Possible Involvement of the Ca1 Gabaa Receptors Upon Acquisition and Expression of the Acpa-Induced Place Preference in Mice, Physiology and Behavior (2016)
43. Synergistic Effect Between Prelimbic 5-Ht3 and Cb1 Receptors on Memory Consolidation Deficit in Adult Male Sprague-Dawley Rats: An Isobologram Analysis, Neuroscience (2016)
44. The Bidirectional Effect of Prelimbic 5-Hydroxytryptamine Type-4 (5-Ht4) Receptors on Acpa-Mediated Aversive Memory Impairment in Adult Male Sprague-Dawley Rats, Iranian Journal of Basic Medical Sciences (2021)
45. Involvement of the Serotonergic System of the Ventral Hippocampus (Ca3) on Amnesia Induced by Acpa in Mice, Behavioural Brain Research (2015)
46. Critical Role of Ca1 Muscarinic Receptors on Memory Acquisition Deficit Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Progress in Neuro-Psychopharmacology and Biological Psychiatry (2017)
47. The Major Neurotransmitter Systems in the Basolateral Amygdala and the Ventral Tegmental Area Mediate Morphine-Induced Memory Consolidation Impairment, Neuroscience (2017)
48. Role of the Amygdala Gaba-A Receptors in Acpa-Induced Deficits During Conditioned Fear Learning, Brain Research Bulletin (2017)
49. Synergistic Antidepressant-Like Effect of Citicoline and Cb 1 Agonist in Male Mice, Psychopharmacology (2024)