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Rotavirus Vp6 Preparations As a Non-Replicating Vaccine Candidates Publisher Pubmed



Jalilvand S1 ; Marashi SM1 ; Shoja Z2
Authors
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Authors Affiliations
  1. 1. Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Virology Department, Pasteur Institute of Iran, Tehran, Iran

Source: Vaccine Published:2015


Abstract

Rotavirus (RV) structural proteins VP4 and VP7, located on the surface of viral particles, elicit neutralizing antibodies (Abs) and are therefore considered to be important components of RV vaccines. However, despite inducing neutralizing Abs, limits of cross-neutralizing activity and lack of full correlation with protection limit the usefulness of these proteins as protective agents against RV disease. VP6 protein, which forms the middle layer of RV particles, is discussed as an alternative vaccine candidate since it can induce cross-protective immune responses against different RV strains although the Ab raised is not neutralizing. This report reviews different functions of VP6 that can lead to considering it as an alternative vaccine against RV disease. © 2015 Elsevier Ltd.
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