Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Co-Loading of Cisplatin and Methotrexate in Nanoparticle-Based Pcl-Peg System Enhances Lung Cancer Chemotherapy Effects Publisher



Akbari E1, 6 ; Mousazadeh H1 ; Hanifehpour Y2 ; Mostafavi E3 ; Gorabi AM10 ; Nejati K8 ; Keyhanvar P4 ; Pazokitoroudi H9 ; Mohammadhosseini M7 ; Akbarzadeh A4, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Biotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Science, Tabriz, Iran
  2. 2. Department of Chemistry, Sayyed Jamaleddin Asadabadi University, Asadabad, Iran
  3. 3. Department of Chemical Engineering, Northeastern University, Boston, 02115, MA, United States
  4. 4. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Universal Scientific Education and Research Network (USERN), Tabriz, Iran
  6. 6. Higher Education Institute of Rab-Rashid, Tabriz, Iran
  7. 7. Department of Chemistry, Shahrood Branch, Islamic Azad University, Shahrood, Iran
  8. 8. Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  9. 9. Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Cluster Science Published:2022


Abstract

Abstract: Since the anticancer drugs exhibited a variety of inhibitory mechanisms in cancer cells, the use of two or more anticancer drugs may have excellent therapeutic effects, particularly in drug-resistant tumors. In this study, the efficient entrapment of two clinically used single-agent drugs, Cisplatin (CDDP) and Methotrexate (MTX) is reported against lung cancer cell lines. Biodegradable polymeric nanoparticles perform to be a favorable environment-responsive controlled drug release system. MTX@CDDP were simultaneously encapsulated into the biodegradable poly (ε-caprolactone) (PCL) modified poly (ethylene glycol) (PEG) copolymer. The spherical nanoparticle was identified via scanning electron microscopy (SEM). Additionally, the antitumor activity and apoptosis induction of designed duel drug-loaded vectors were assessed against A549 cell lines by qRT-PCR, MTT assay, and DAPI staining. The nanoformulation loaded with MTX@CDDP statistically reduced the cell activity of A549. The results indicate that MTX@CDDP-loaded PCL-PEG nanoparticles can be further utilized for treating non-small-cell lung cancer as a promising therapeutic approach. Graphical Abstract: [Figure not available: see fulltext.]. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Related Docs
1. Biodegradable Functional Macromolecules As Promising Scaffolds for Cardiac Tissue Engineering, Polymers for Advanced Technologies (2022)
2. Recent Advances in Plga-Based Nanofibers As Anticancer Drug Delivery Systems, Journal of Drug Delivery Science and Technology (2023)
3. Preparation and Evaluation of Doxorubicin-Loaded Pla–Peg–Fa Copolymer Containing Superparamagnetic Iron Oxide Nanoparticles (Spions) for Cancer Treatment: Combination Therapy With Hyperthermia and Chemotherapy, International Journal of Nanomedicine (2020)
4. A Review on Drug Delivery Systems Containing Polymer Nanocomposites for Breast Cancer Treatment, Polymer Reviews (2024)
5. Enhancing Sirna Cancer Therapy: Multifaceted Strategies With Lipid and Polymer-Based Carrier Systems, International Journal of Pharmaceutics (2024)
6. Encapsulation for General Cancer Treatment, Principles of Biomaterials Encapsulation: Volume 2 (2023)
Experts (# of related papers)
View all Related Experts
Rassoul Dinarvand (2)
Fatemeh Atyabi (1)