Calcium Dobesilate Protects Against D-Galactose-Induced Hepatic and Renal Dysfunction, Oxidative Stress, and Pathological Damage

Calcium Dobesilate Protects Against D-Galactose-Induced Hepatic and Renal Dysfunction, Oxidative Stress, and Pathological Damage Publisher Pubmed

Hakimizadeh E¹ ; Zamanian MY^{2, 3} ; Damankhorshid M¹ ; Gimenezllort L⁴ ; Sciorati C⁵ ; Nikbakhtzadeh M⁶ ; Moradbeygi K^{6, 7} ; Kujawska M⁸ ; Kaeidi A^{1, 9} ; Taghipour Z¹⁰ ; Fatemi I¹¹

Show Affiliations

1. Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2. Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3. Department of Toxicology and Pharmacology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4. Institute of Neuroscience and Department of Psychiatry and Forensic Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain
5. Division of Immunology, Transplantation and Infectious Diseases, IRCCS Ospedale San Raffaele Scientific Institute, Milan, Italy
6. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Nursing, Abadan Faculty of Medical Sciences, Abadan, Iran
8. Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland
9. Department of Physiology and Pharmacology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
10. Department of Anatomy, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
11. Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

Source: Fundamental and Clinical Pharmacology Published:2022

Abstract

Calcium dobesilate (CaD) is used for the treatment of diabetic retinopathy and nephropathy. This agent exerts antioxidant effects. In the present study, we evaluated the protective effects of oral administration of CaD against hepatorenal damages in a mice model of aging induced by d-galactose (d-gal). We used 28 male albino mice, which equally and randomly were divided into four groups as follows: intact, aging (d-gal at the dose of 500 mg/kg, p.o.), aging + CaD 50 (d-gal plus CaD at the dose of 50 mg/kg), and aging + CaD 100 (d-gal plus CaD at the dose of 100 mg/kg, p.o.). All drugs were administered orally once a day for 42 days. The liver and kidney damages were evaluated by measuring mass indices, levels of serum creatinine and blood urea nitrogen, and activities of serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase and by histopathological evaluation. Moreover, hepatic and renal tissue oxidant/antioxidant markers (malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase) were measured. The results showed that d-gal treatment induced significant oxidative stress in the kidney and liver that was paralleled by dysfunctions and histological alterations of these organs. CaD significantly improved the liver and kidney indices, implemented functional capacity of the liver and kidney, as well as decreased oxidative stress enhancing antioxidative enzyme activities. CaD treatment also inhibited the development of histological alterations of both kidney and liver. CaD might represent a promising therapeutic agent for the attenuation of hepatorenal injuries induced by aging. © 2022 Societe Francaise de Pharmacologie et de Therapeutique.

2. Ellagic Acid Mitigates Sodium Arsenite-Induced Renal and Hepatic Toxicity in Male Wistar Rats, Pharmacological Reports (2018)

3. Involvement of 5-Ht1b/1D Receptors in the Inflammatory Response and Oxidative Stress in Intestinal Ischemia/Reperfusion in Rats, European Journal of Pharmacology (2020)

4. Protective Effect of Camel Milk on Gentamicin-Induced Nephrotoxicity:From Renal Biomarkers to Histopathology Evidence, Iranian Journal of Veterinary Medicine (2021)

5. Effects of Modafinil (Provigil) on Memory and Learning in Experimental and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular Mechanisms and Behavioural Effects, Current Molecular Pharmacology (2023)

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Style	Citing Format
MLA	Hakimizadeh E, et al.. "Calcium Dobesilate Protects Against D-Galactose-Induced Hepatic and Renal Dysfunction, Oxidative Stress, and Pathological Damage." Fundamental and Clinical Pharmacology, vol. 36, no. 4, 2022, pp. 721-730.
APA	Hakimizadeh E, Zamanian MY, Damankhorshid M, Gimenezllort L, Sciorati C, Nikbakhtzadeh M, Moradbeygi K, Kujawska M, Kaeidi A, Taghipour Z, Fatemi I (2022). Calcium Dobesilate Protects Against D-Galactose-Induced Hepatic and Renal Dysfunction, Oxidative Stress, and Pathological Damage. Fundamental and Clinical Pharmacology, 36(4), 721-730.
Chicago	Hakimizadeh E, Zamanian MY, Damankhorshid M, Gimenezllort L, Sciorati C, Nikbakhtzadeh M, Moradbeygi K, et al.. "Calcium Dobesilate Protects Against D-Galactose-Induced Hepatic and Renal Dysfunction, Oxidative Stress, and Pathological Damage." Fundamental and Clinical Pharmacology 36, no. 4 (2022): 721-730.
Harvard	Hakimizadeh E et al. (2022) 'Calcium Dobesilate Protects Against D-Galactose-Induced Hepatic and Renal Dysfunction, Oxidative Stress, and Pathological Damage', Fundamental and Clinical Pharmacology, 36(4), pp. 721-730.
Vancouver	Hakimizadeh E, Zamanian MY, Damankhorshid M, Gimenezllort L, Sciorati C, Nikbakhtzadeh M, et al.. Calcium Dobesilate Protects Against D-Galactose-Induced Hepatic and Renal Dysfunction, Oxidative Stress, and Pathological Damage. Fundamental and Clinical Pharmacology. 2022;36(4):721-730.
BibTex	@article{ author = {Hakimizadeh E and Zamanian MY and Damankhorshid M and Gimenezllort L and Sciorati C and Nikbakhtzadeh M and Moradbeygi K and Kujawska M and Kaeidi A and Taghipour Z and Fatemi I}, title = {Calcium Dobesilate Protects Against D-Galactose-Induced Hepatic and Renal Dysfunction, Oxidative Stress, and Pathological Damage}, journal = {Fundamental and Clinical Pharmacology}, volume = {36}, number = {4}, pages = {721-730}, year = {2022} }
RIS	TY - JOUR AU - Hakimizadeh E AU - Zamanian MY AU - Damankhorshid M AU - Gimenezllort L AU - Sciorati C AU - Nikbakhtzadeh M AU - Moradbeygi K AU - Kujawska M AU - Kaeidi A AU - Taghipour Z AU - Fatemi I TI - Calcium Dobesilate Protects Against D-Galactose-Induced Hepatic and Renal Dysfunction, Oxidative Stress, and Pathological Damage JO - Fundamental and Clinical Pharmacology VL - 36 IS - 4 SP - 721 EP - 730 PY - 2022 ER -

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