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Hexyltriphenylphosphonium Bromide As an Absolutely Chemoselective Ionic Liquid Catalyst in the Three-Component Reaction of Aryl Aldehydes, Acetophenones and Malononitrile Publisher



Bahrami K1 ; Khodaei MM1 ; Batooie N1 ; Hosseinzadeh N2 ; Foroumadi A3
Authors
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Authors Affiliations
  1. 1. Department of Organic Chemistry, Faculty of Chemistry, Razi University, Kermanshah, 67149-67346, Iran
  2. 2. Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, Azadi Street, PO Box 11155–9516, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: ChemistrySelect Published:2019


Abstract

Hexyltriphenylphosphonium bromide (HTPB) is used as an efficient ionic liquid catalyst in the chemoselective addition of malononitrile to carbonyl group moiety of chalcones through the three-component reaction of aryl aldehydes, acetophenone derivatves, and malononitrile to produce (E)-2-(1,3-diarylallylidene)malononitriles at ambient temperature. The method is simple, solvent-free, environmentally friendly, and gives excellent yields in a short reaction times. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim