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Association of Angiotensin-Converting Enzyme (Ace) I/D Variation With Biochemical Parameters and Oxidative Stress Markers in Systemic Lupus Erythematosus Patients in West of Iran Publisher Pubmed



Kiani A1 ; Eliehalikomi D2, 3 ; Bahrehmand F4 ; Mostafaei S5 ; Vaisiraygani A6 ; Baniamerian H6 ; Aghaz F6 ; Tanhapour M7 ; Shakiba E8 ; Rahimi Z4 ; Pourmotabbed T9
Authors
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Authors Affiliations
  1. 1. Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Institute of Allergology, Charite – Universitatsmedizin Berlin, Corporate member of Freie Universitat Berlin and Humboldt-Universitat Zu Berlin, Berlin, Germany
  3. 3. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany
  4. 4. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
  6. 6. Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  7. 7. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Behavioral Disease Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  9. 9. Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States

Source: Molecular Biology Reports Published:2023


Abstract

Purpose: We aimed to study insertion/deletion (I/D) variation (rs4646994) of ACE gene in a group of SLE patients in west of Iran and its possible relationship with oxidative stress. Method and results: Genotypes and allele frequencies related to ACE (I/D) variation were determined in 108 SLE patients and 110 gender and age-matched healthy controls using PCR. Neopterin, malondialdehyde (MDA), and serum lipid concentrations were determined by HPLC and enzyme assay respectively. The overall distribution of ACE I/D genotypes in SLE patients was different from that of the control group (P = 0.005). DD genotype compared to ID genotype increased the risk of SLE (OR = 2.57, 95% CI 1.4–4.8, P = 0.003). ID genotype compared to the II genotype decreased the risk of disease (OR = 0.45, 95% CI 0.2–0.99, p = 0.042). SLE patients with DD, ID, and II genotypes had lower paraoxonase (PON) activity and higher serum levels of MDA and neopterin versus control patients. We also detected a significant protective effect against SLE in presence of ACE I alleles and lack of angiotensin II receptor, type 1 (AGTR1) A1166C (NCBI reference SNP id: rs5186), C alleles in this study (OR = 0.31, 95% CI 0.14–0.68, P = 0.002). Conclusions: Carriers of the DD genotype of ACE gene with higher serum concentrations of neopterin and MDA, and lower PON activity had a high risk to develop SLE, while ID genotype decreased the risk of disease development by 2.22 times compared to II genotype. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.
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