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The Association Between Vitamin D Deficiency and Variants of Vitamin D Binding Protein Gene Among Healthy Iranian Adults Publisher Pubmed



Pooyan S1 ; Rahimi MH1 ; Mollahosseini M1 ; Khorraminezhad L1 ; Maghbooli Z2 ; Mirzaei K1
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P. O. Box: 14155-6117, Tehran, Iran
  2. 2. Multiple Sclerosis Research Center, Neuroscience Institute of Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal for Vitamin and Nutrition Research Published:2020


Abstract

Background: The high prevalence of vitamin D deficiency may be due to both genetic and environment factors. The aim of this study was to demonstrate that vitamin D deficiency may be due to variants of vitamin D binding protein (DBP) among otherwise healthy Iranian adults. Methods: This cross-sectional study was conducted on 265 healthy adults in Tehran. Anthropometric and biochemical parameters were assessed. Dietary vitamin D intake was assessed with a Food Frequency Questionnaire (FFQ), and participant DBP genotypes were determined by polymerase chain reactions-restriction fragment length polymorphism. Results: Significant associations were found between vitamin D status and low-density lipoprotein cholesterol (P < 0.001), total cholesterol (P < 0.001), and fasting blood sugar (P < 0.001), after adjustment for confounder factors. This study demonstrated that rs7041 gene was associated with vitamin D deficiency (OR = 0.63, β ± SE = 0.46 ± 0.14, P < 0.0001). After considering the GG genotype of the rs7041 polymorphism as a reference, the prevalence of vitamin D deficiency was found to be higher in the individuals with TT genotype from the rs7041 polymorphism. Conclusion: It was found that the prevalence of vitamin D deficiency was higher in individuals with T allele carriers in the rs7041 polymorphism. © 2020 Hogrefe.
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