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Mitigating Effects of Agmatine on Myocardial Infarction in Rats Subjected to Isoproterenol Publisher Pubmed



Eliehalikomi D1, 2 ; Yarmohammadi F3 ; Nezamabadi M4 ; Khirehgesh MR5 ; Kiani M6 ; Rashidi K7 ; Mohammadinoori E5 ; Salehi N8 ; Dehpour AR9, 10 ; Kiani A5, 6
Authors
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Authors Affiliations
  1. 1. Institute of Allergology, Charite – Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat Zu Berlin, Berlin, Germany
  2. 2. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany
  3. 3. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  7. 7. Oils & Fats Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  8. 8. Cardiovascular Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  9. 9. Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Naunyn-Schmiedeberg's Archives of Pharmacology Published:2025


Abstract

Isoproterenol (ISO) usage is limited by its potential for cardiotoxicity. We sought to investigate the potential of agmatine in mitigating ISO-induced cardiotoxicity. Agmatine (100 mg/kg/day) was intraperitoneally administered to Wistar rats for 7 days in the presence or absence of cardiotoxicity induced by subcutaneous injection of ISO (85 mg/kg) on the sixth and seventh days. ECG parameters, lactate dehydrogenase (LDH), malondialdehyde (MDA), and creatinine phosphokinase (CPK) were investigated. Changes in cardiac tissue were also investigated using H&E staining. The heart weight/body weight ratio increased in ISO-treated rats. In the agmatine + ISO group, the increased heart rate observed in ISO-treated rats was reversed (317.2 ± 10.5 vs 452.2 ± 10.61, P < 0.001). Agmatine ameliorated the change in PR, RR, and ST intervals and the QRS complex, which was reduced by ISO. Treatment with saline, ISO, and agmatine had no significant effect on papillary muscle stimulation (P > 0.05). The administration of agmatine to ISO-receiving group could mitigate several parameters when compared to ISO-receiving group including increasing papillary muscle contraction (0.83 vs 0.71 N/M2 respectively, P < 0.01), decreasing LDH levels (660 ng/ml vs 1080 ng/ml, respectively, P < 0.05), decreasing CPK levels (377 U/l vs 642 U/l, respectively, P < 0.05) and decreasing MDA levels (20.32 µM/l vs 46.83 µM/l, P < 0.001). Coadministration of agmatine and ISO is capable of ameliorating ISO cardiotoxicity by antioxidant effects and controlling the hemostasis of calcium in myocytes. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
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