Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering

Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering Publisher

Salati MA¹ ; Khazai J¹ ; Tahmuri AM¹ ; Samadi A¹ ; Taghizadeh A² ; Taghizadeh M² ; Zarrintaj P³ ; Ramsey JD³ ; Habibzadeh S⁴ ; Seidi F⁵ ; Saeb MR⁶ ; Mozafari M⁷

Show Affiliations

1. Polymer Engineering Department, Faculty of Engineering, Urmia University, Urmia, 5756151818, Iran
2. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, 11155-4563, Iran
3. School of Chemical Engineering, Oklahoma State University, 420 Engineering North, Stillwater, 74078, OK, United States
4. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, 1591639675, Iran
5. Provincial Key Lab of Pulp and Paper Science and Technology and Joint International Research Lab of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing, 210037, China
6. Department of Resin and Additives, Institute for Color Science and Technology, Tehran, P.O. Box 16765-654, Iran
7. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 144961-4535, Iran

Source: Polymers Published:2020

Abstract

The lack of adequate blood/lymphatic vessels as well as low-potential articular cartilage regeneration underlines the necessity to search for alternative biomaterials. Owing to their unique features, such as reversible thermogelling behavior and tissue-like mechanical behavior, agarose-based biomaterials have played a key role in cartilage tissue repair. Accordingly, the need for fabricating novel highly efficient injectable agarose-based biomaterials as hydrogels for restoration of injured cartilage tissue has been recognized. In this review, the resources and conspicuous properties of the agarose-based biomaterials were reviewed. First, different types of signals together with their functionalities in the maintenance of cartilage homeostasis were explained. Then, various cellular signaling pathways and their significant role in cartilage tissue engineering were overviewed. Next, the molecular structure and its gelling behavior have been discussed. Eventually, the latest advancements, the lingering challenges, and future ahead of agarose derivatives from the cartilage regeneration perspective have been discussed. © 2020 by the authors.

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Fatameh Mottaghitalab (5)

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Style	Citing Format
MLA	Salati MA, et al.. "Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering." Polymers, vol. 12, no. 5, 2020, pp. -.
APA	Salati MA, Khazai J, Tahmuri AM, Samadi A, Taghizadeh A, Taghizadeh M, Zarrintaj P, Ramsey JD, Habibzadeh S, Seidi F, Saeb MR, Mozafari M (2020). Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering. Polymers, 12(5), -.
Chicago	Salati MA, Khazai J, Tahmuri AM, Samadi A, Taghizadeh A, Taghizadeh M, Zarrintaj P, et al.. "Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering." Polymers 12, no. 5 (2020): -.
Harvard	Salati MA et al. (2020) 'Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering', Polymers, 12(5), pp. -.
Vancouver	Salati MA, Khazai J, Tahmuri AM, Samadi A, Taghizadeh A, Taghizadeh M, et al.. Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering. Polymers. 2020;12(5):-.
BibTex	@article{ author = {Salati MA and Khazai J and Tahmuri AM and Samadi A and Taghizadeh A and Taghizadeh M and Zarrintaj P and Ramsey JD and Habibzadeh S and Seidi F and Saeb MR and Mozafari M}, title = {Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering}, journal = {Polymers}, volume = {12}, number = {5}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Salati MA AU - Khazai J AU - Tahmuri AM AU - Samadi A AU - Taghizadeh A AU - Taghizadeh M AU - Zarrintaj P AU - Ramsey JD AU - Habibzadeh S AU - Seidi F AU - Saeb MR AU - Mozafari M TI - Agarose-Based Biomaterials: Opportunities and Challenges in Cartilage Tissue Engineering JO - Polymers VL - 12 IS - 5 SP - EP - PY - 2020 ER -

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