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Serum Inflammatory Markers As Prognostic Marker for Nasopharyngeal Carcinoma With Liver Metastasis: A Multi-Center Retrospective Study Publisher Pubmed



Saboorifar H1 ; Zafarani Y2 ; Gholampour G3 ; Roghani A4, 5 ; Qiu F6 ; Dequaniter D8 ; Yu Q9
Authors
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Authors Affiliations
  1. 1. Department of Head and Neck Surgery, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Head and Neck Surgery, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  3. 3. Department of Head and Neck Surgery, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Head and Neck Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Department of Radiation Oncology, Fujian Cancer Hospital & amp
  7. 7. Fujian Medical University Cancer Hospital, Fuzhou, China
  8. 8. Medicine Faculty, Universite Libre de Bruxelles (ULB), Route de Lennik 808, Brussels, Belgium
  9. 9. Otorhinolaryngology and Maxillofacial Department, First Affiliated Hospital of Nanchang University, Nanchang, China

Source: European Archives of Oto-Rhino-Laryngology Published:2024


Abstract

Background: This retrospective study investigated the prognostic value of serum inflammatory markers in nasopharyngeal carcinoma (NPC) patients, focusing on their association with overall survival (OS) and liver metastasis-free survival (LMFS). Methods: The study included 314 NPC patients treated between 2010 and 2020. Clinical characteristics, treatment methods, and serum inflammatory markers were assessed. Patients were categorized into two groups of with and without liver metastasis. Univariate and multivariate Cox regression and Kaplan–Meier survival analyses were performed to investigate the prognostic value of serum inflammatory markers in NPC patients with and without liver metastasis. Results: In the whole cohort, univariate Cox regression analysis singled out tumor necrosis factor-α (TNF-α) (HR = 1.57, 95% CI 1.44–4.90, p = 0.004) and neutrophil-to-lymphocyte ratio (NLR) (HR = 2.13, 95% CI 1.33–3.99, p = 0.009), which were significantly associated with poorer OS. In patients with liver metastasis, TNF-α and NLR could not independently predict OS. However, high TNF-α levels were independently associated with worse OS in patients without liver metastasis (HR (95% CI) = 2.75 (1.67–8.68), p < 0.001). High NLR levels could independently predict poor OS in both groups with (HR (95% CI) = 1.94 (1.77–6.38), p = 0.010) and without liver metastasis (HR (95% CI) = 1.58 (1.19–7.54), p = 0.009). Ultimately, TNF-α and NLR could not significantly predict LMFS. Conclusion: This study highlights the prognostic significance of TNF-α and NLR in NPC patients, especially in those with liver metastasis. These inflammatory markers could serve as valuable indicators for assessing the prognosis of NPC patients. Further research is warranted to validate their clinical utility and explore potential therapeutic implications. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
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