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Facile Fabrication and Characterization of a Novel Oral Ph-Sensitive Drug Delivery System Based on Cmc Hydrogel and Hnt-At Nanohybrid Publisher Pubmed



Hossieniaghdam SJ1 ; Foroughinia B2 ; Zareakbari Z3 ; Mojaradjabali S4 ; Motasadizadeh H5 ; Farhadnejad H6
Authors
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Authors Affiliations
  1. 1. Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Dezful University of Medical Sciences, Dezful, Iran
  3. 3. School of Sciences, Islamic Azad University, Tabriz, Iran
  4. 4. Iran Polymer and Petrochemical Institute (IPPI), Tehran, Iran
  5. 5. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  6. 6. Students’ Research Committee, Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2018


Abstract

The main aim of the present study was to design pH-sensitive bionanocomposite hydrogel beads based on CMC and HNT-AT nanohybrid and evaluate whether prepared bionanocomposite beads have the potential to be used in drug delivery applications. Atenolol (AT), as a model drug, was incorporated into the lumen of HA nanotubes via the co-precipitation technique. HNT/AT nanohybrid and CMC/HNT-AT beads were characterized via XRD, SEM, TGA, and FT-IR techniques. Drug loading and encapsulation efficiency was found to be high for CMC/HNT3 beads. Moreover, the swelling and drug release properties of the prepared CMC/HA-AT beads were investigated, and showed a pH sensitive swelling behavior with maximum its content at pH 6.8. Also, it was found that the swelling ratio of CMC/HNT beads was lower than that of pristine CMC beads. Drug release behavior of CMC/HNT-AT bionanocomposite hydrogel beads were investigated. A more sustained and controlled drug releases were observed for CMC/HNT-AT beads. © 2017 Elsevier B.V.
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