Exploring Genetic Signatures of Obesity: Hub Genes and Mirnas Unveiled Through Comprehensive Bioinformatic Analysis Publisher



Tamkini M¹ ; Nourbakhsh M^{2, 3} ; Movahedi M¹ ; Golestani A⁴ Show Affiliations
Source: Journal of Diabetes and Metabolic Disorders Published:2024

Abstract

Objectives: Adipogenesis, the process of fat accumulation in adipose tissue, is closely linked to obesity, a condition characterized by excessive fat storage. Genetic factors significantly contribute to an individual's susceptibility to adipogenesis and the development of obesity. Methods: In this study, we conducted a comprehensive bioinformatic analysis, including Weighted Gene Co-expression Analysis, differentially expressed gene analysis, and protein–protein interaction analysis, to identify hub genes and miRNAs associated with obesity. Results: Our findings highlight the potential involvement of genes such as ATP5F1A, FN1, CCl2, RPS14, and RPS16, as well as miRNAs including hsa-miR-6844, hsa-miR-4528, hsa-miR-3686, hsa-miR-3124-3p, hsa-miR-381-3p, and hsa-miR-300 in obesity. Conclusions: The findings from this study contribute to the growing knowledge of adipogenesis and obesity genetics, and provide potential biomarkers for further investigation and translation into clinical or research applications. Graphical abstract: (Figure presented.) © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024. corrected publication 2024.