Biomarker Profile of Colorectal Cancer: Current Findings and Future Perspective Publisher



Hoseini SH¹ ; Enayati P² ; Nazari M^{3, 4} ; Babakhanzadeh E⁵ ; Rastgoo M⁶ ; Sohrabi NB⁷ Show Affiliations
Source: Journal of Gastrointestinal Cancer Published:2024

Abstract

Objective: Breakthroughs in omics technology have led to a deeper understanding of the fundamental molecular changes that play a critical role in the development and progression of cancer. This review delves into the hidden molecular drivers of colorectal cancer (CRC), offering potential for clinical translation through novel biomarkers and personalized therapies. Methods: We summarizes recent studies utilizing various omics approaches, including genomics, transcriptomics, proteomics, epigenomics, metabolomics and data integration with computational algorithms, to investigate CRC. Results: Integrating multi-omics data in colorectal cancer research unlocks hidden biological insights, revealing new pathways and mechanisms. This powerful approach not only identifies potential biomarkers for personalized prognosis, diagnosis, and treatment, but also predicts patient response to specific therapies, while computational tools illuminate the landscape by deciphering complex datasets. Conclusions: Future research should prioritize validating promising biomarkers and seamlessly translating them into clinical practice, ultimately propelling personalized CRC management to new heights. © 2024, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.