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Hiv Drug Resistance and Phylogeny Profile in Naive and Antiretroviral-Experienced Patients in Tehran, Iran Publisher Pubmed



Farrokhi M1 ; Moallemi S1 ; Baesi K2 ; Ahsaninasab S1 ; Gholami M1 ; Sadeghi L1 ; Mohraz M1
Authors
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Authors Affiliations
  1. 1. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, 14115-331, Iran

Source: Intervirology Published:2017


Abstract

Background: Increasing the accessibility of antiretroviral therapy (ART) has caused the emergence of drug resistance in patients receiving ART and in naive patients. The aim of this study was to evaluate HIV subtype and drug resistance between naive patients and ART-experienced patients. Methods: Blood samples were collected from 78 antiretroviral and naive HIV-1 patients; antiretroviral-resistant mutations and subtyping were then determined by sequencing pol regions. Results: Phylogenetic analysis revealed that 96.1% of sequences belong to the CRF35-AD subtype. Transmitted drug resistance was determined in 14% of drug-naive patients and 40% of ART-experienced patients. Conclusion: The findings of this study illustrated the importance of resistance testing before and during ART treatment. This study can be used to set up a best medicine strategy in Iranian guidelines. © 2016 S. Karger AG, Basel.
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