There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence

There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence Publisher Pubmed

Nili M¹ ; Tayeri K² ; Gholami M¹ ; Moallemi S² ; Sabahi F¹ ; Kalhori S⁴ ; Baesi K³ ; Hasibi M²

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1. Department of Virology, Tarbiat Modares University, Tehran, Iran
2. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
3. Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran
4. Qazvin University of Medical Sciences, Qazvin, Iran

Source: Infectious Disorders - Drug Targets Published:2019

Abstract

Background: The rate of human immunodeficiency virus type 1 (HIV-1) infection in Iran has increased dramatically in the past few years. HIV-1 genome sequences are pivotal for large-scale studies of inter-and intra-host evolution. To understand the molecular difference between reference HIV-1 isolate and two HIV-1 infected patients in Iran, we conducted this study to analyze some genome segments of Iranian HIV-1 isolates. Methods: Two HIV-1-infected individuals who were under antiretroviral therapy (ARV) for 8 years with stable clinical status were enrolled. The patient’s plasma samples were used for the Gag-Pol genome sequences (4500 nt). The phylogenetic tree and similarity plotty were obtained based on Gag-Pol sequences. Results: Both HIV-1-infected isolates belonged to CRF35_AD subtype even though one of them had drug resistance. The HIV genome and protein sequences showed no clear difference between genome and protein sequences of our samples and the reference sequence. Conclusions:whichOurcouldpatient’sbe owingstableto clinicalimmunologicalstatus hadfactorsno connectionor other patient’sto genomemodese-quence; which are still unknown. © 2019 Bentham Science Publishers.

2. Crf35-Ad As the Main Circulating Genotype of Human Immunodeficiency Virus Type 1 Infection in Iran: A Phylogenetic and Demographic-Based Study, Intervirology (2018)

3. Phylogeny and Drug Resistance of Hiv Pr Gene Among Hiv Patients Receiving Rt Inhibitors in Iran, Asian Pacific Journal of Tropical Biomedicine (2016)

4. Hiv Drug Resistance and Phylogeny Profile in Naive and Antiretroviral-Experienced Patients in Tehran, Iran, Intervirology (2017)

5. Antiretroviral Drug Resistance Mutations Among Hiv Treatment Failure Patients in Tehran, Iran, Iranian Journal of Public Health (2017)

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Style	Citing Format
MLA	Nili M, et al.. "There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence." Infectious Disorders - Drug Targets, vol. 19, no. 1, 2019, pp. 67-72.
APA	Nili M, Tayeri K, Gholami M, Moallemi S, Sabahi F, Kalhori S, Baesi K, Hasibi M (2019). There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence. Infectious Disorders - Drug Targets, 19(1), 67-72.
Chicago	Nili M, Tayeri K, Gholami M, Moallemi S, Sabahi F, Kalhori S, Baesi K, Hasibi M. "There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence." Infectious Disorders - Drug Targets 19, no. 1 (2019): 67-72.
Harvard	Nili M et al. (2019) 'There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence', Infectious Disorders - Drug Targets, 19(1), pp. 67-72.
Vancouver	Nili M, Tayeri K, Gholami M, Moallemi S, Sabahi F, Kalhori S, et al.. There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence. Infectious Disorders - Drug Targets. 2019;19(1):67-72.
BibTex	@article{ author = {Nili M and Tayeri K and Gholami M and Moallemi S and Sabahi F and Kalhori S and Baesi K and Hasibi M}, title = {There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence}, journal = {Infectious Disorders - Drug Targets}, volume = {19}, number = {1}, pages = {67-72}, year = {2019} }
RIS	TY - JOUR AU - Nili M AU - Tayeri K AU - Gholami M AU - Moallemi S AU - Sabahi F AU - Kalhori S AU - Baesi K AU - Hasibi M TI - There Is No Difference Between Sequences of Hiv-1 Infected Patients With Stable Clinical Status and Hiv-1 Reference Sequence JO - Infectious Disorders - Drug Targets VL - 19 IS - 1 SP - 67 EP - 72 PY - 2019 ER -

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