Burden of Upper Gastrointestinal Cancers in the East of Golestan Province (Golestan Cohort Study) Publisher Pubmed



Jahani MA¹ ; Esmaeili R² ; Abbasi M³ ; Nikbakht HA¹ ; Azarbakhsh H⁴ ; Roshandel G⁵ ; Delavari S⁶ ; Shojaie L⁷ ; Mahmoudi G⁸ Show Affiliations
Source: Cancer Reports Published:2024

Abstract

Background: Cancers, especially Upper Gastrointestinal Cancers (UGCs), pose a substantial burden on society, particularly in developing nations. Golestan province, Iran, is known for its high UGC rates globally. Aims: This study delves into the disease burden of UGCs in the eastern part of Golestan province. Methods and Results: This study was conducted using the results of the Golestan cohort study. 2711 patients participating in this cohort, who visited Atrak Clinic during 2001–2020, participated in this study. After excluding patients with incomplete records, 2481 patients were included in the study. To compute the metrics of years of life lost (YLL), years of life lived with disability (YLD), and disability-adjusted life years (DALY), we utilized the World Health Organization's standard life table, stratified by age and gender. The majority of UGC patients in our study were married (81.8%), had limited formal education (82.6%), and were predominantly male (61.1%). A substantial proportion resided in suburban areas (85.8%), and over half of the patients (52%) reported a history of drug addiction. The mean age at diagnosis for men was 65.76 years with a standard deviation of 11.34, while for women, it was 64.38 years with a standard deviation of 11.66. Regarding disease impact, YLL, YLD, and DALY for men were 21 240, 1956, and 23 196 (307.8 per 100 000), respectively. For women, these figures were 15 609 for YLL, 1367 for YLD, and 16 976 (223.1 per 100 000) for DALY. Conclusion: After the increasing trend of the burden of UGCs in Golestan province in the early years of the study, this rate has been decreasing in recent years. Effective strategies necessitate collaborative efforts across various sectors to alleviate this burden, focusing on preventive measures, timely diagnosis, and well-coordinated therapeutic interventions. © 2024 The Authors. Cancer Reports published by Wiley Periodicals LLC.