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Emerging Roles of Non-Coding Rnas in Modulating the Pi3k/Akt Pathway in Cancer Publisher



Hashemi M1, 2 ; Mohandesi Khosroshahi E1, 2 ; Asadi S1, 2 ; Tanha M3 ; Ghatei Mohseni F1 ; Abdolmohammad Sagha R1 ; Taheri E1 ; Vazayefi P1 ; Shekarriz H1 ; Habibi F1 ; Mortazi S1 ; Khorrami R4 ; Nabavi N5 ; Rashidi M6, 7 Show All Authors
Authors
  1. Hashemi M1, 2
  2. Mohandesi Khosroshahi E1, 2
  3. Asadi S1, 2
  4. Tanha M3
  5. Ghatei Mohseni F1
  6. Abdolmohammad Sagha R1
  7. Taheri E1
  8. Vazayefi P1
  9. Shekarriz H1
  10. Habibi F1
  11. Mortazi S1
  12. Khorrami R4
  13. Nabavi N5
  14. Rashidi M6, 7
  15. Taheriazam A1, 8
  16. Rahimzadeh P9
  17. Entezari M1, 2
Show Affiliations
Authors Affiliations
  1. 1. Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  2. 2. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  3. 3. Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, United States
  4. 4. Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  5. 5. Independent Researchers, Victoria, V8V 1P7, BC, Canada
  6. 6. Department Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. The Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  8. 8. Department of Orthopedics, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  9. 9. Surgical Research Society (SRS), Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Non-coding RNA Research Published:2025


Abstract

Cancer progression results from the dysregulation of molecular pathways, each with unique features that can either promote or inhibit tumor growth. The complexity of carcinogenesis makes it challenging for researchers to target all pathways in cancer therapy, emphasizing the importance of focusing on specific pathways for targeted treatment. One such pathway is the PI3K/Akt pathway, which is often overexpressed in cancer. As tumor cells progress, the expression of PI3K/Akt increases, further driving cancer advancement. This study aims to explore how ncRNAs regulate the expression of PI3K/Akt. NcRNAs are found in both the cytoplasm and nucleus, and their functions vary depending on their location. They can bind to the promoters of PI3K or Akt, either reducing or increasing their expression, thus influencing tumorigenesis. The ncRNA/PI3K/Akt axis plays a crucial role in determining cell proliferation, metastasis, epithelial-mesenchymal transition (EMT), and even chemoresistance and radioresistance in human cancers. Anti-tumor compounds can target ncRNAs to modulate the PI3K/Akt axis. Moreover, ncRNAs can regulate the PI3K/Akt pathway both directly and indirectly. © 2024 The Authors
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