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Anti-Inflammatory Effects of Curcumin-Loaded Niosomes on Respiratory Syncytial Virus Infection in a Mice Model Publisher Pubmed



Samadizadeh S1, 2 ; Arabi MS3 ; Yasaghi M1, 2 ; Salimi V4 ; Tabarraei A2 ; Moradi A2 ; Tahamtan A1, 2
Authors
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Authors Affiliations
  1. 1. Infectious Diseases Research Centre, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  4. 4. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Medical Microbiology Published:2022


Abstract

Introduction. Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in paediatrics. While antivirals are apparent candidates to treat RSV-induced diseases, they have not yet met expectations and have remained in infancy. There is growing evidence to suggest that modulating the exacerbated inflammation during RSV infection can improve disease outcome. Hypothesis. Curcumin-loaded niosomes have anti-inflammatory effects against RSV-induced respiratory disease by reducing immune cells' infiltration and inflammatory cytokines' production. Aim. This study evaluated the effects of curcumin-loaded niosomes on RSV-induced immunopathology in a mice model. Methodologies. Curcumin-loaded niosomes were prepared using the thin-film hydration method and characterized in vitro. Female Balb/c mice were infected by RSV-A2 and treated daily with curcumin-loaded niosomes. The potential anti-inflammatory effects of curcumin-loaded niosomes were evaluated on day 5 after infection. Results. Using curcumin-loaded niosomes decreased immune cell influx and the inflammatory mediators (MIP-1α, TNF-α and IFN-γ) production in the lung, resulting in alleviated lung pathology following RSV infection. Conclusion. These findings indicate that curcumin-loaded niosomes have anti-inflammatory potential and could be a promising candidate to alleviate RSV-associated immunopathology. © 2022 The Authors
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