Morphine Addiction Is Tolerated Better in Socialized Male Rats

Morphine Addiction Is Tolerated Better in Socialized Male Rats Publisher

Famitafreshi H¹ ; Karimian M²

Show Affiliations

1. Department of Physiology, Tehran University of Medical Science-International Campus, Tehran, Iran
2. Department of Physiology, Tehran University of Medical Science, Tehran, Iran

Source: Sleep and Hypnosis Published:2018

Abstract

Drug abuse in some addicts progresses to compulsive drug seeking and taking behaviors. High-risk addictive behaviors tend to make interactions between an addict and the community more complex. Socialization is a necessary process that needs to be developed to accommodate to social life.The aim of this study was to evaluate the benefits of social interaction during addiction. Forty two (42) male Sprague-Dawley rats were randomly divided into four groups: social, isolated, socialized morphine-treated (SMT) and isolated morphine-treated (IMT). At the end of the study, neurogenesis, corticosterone, nitrite/nitrate, anhedonia with forced swim test and sucrose and salt craving were examined. Neurogenesis was reduced in IMT group compared to SMT group. SMT animals and control demonstrated better forced swim test performance compared to IMT animals. Furthermore, sucrose and salt (NaCl 3%) consumption was found to be higher in IMT animals compared to SMT animals. Corticosterone was higher in IMT rats compared to SMT rats. Nitrite/nitrate was higher in IMT rats compared to SMT rats. Socialization preserves brain functions necessary for life. Hence, socialized addicts can better tolerate addiction-induced adverse effects.

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Seyed Morteza Karimian (6)

Nima Rezaei (1)

Style	Citing Format
MLA	Famitafreshi H, Karimian M. "Morphine Addiction Is Tolerated Better in Socialized Male Rats." Sleep and Hypnosis, vol. 20, no. 1, 2018, pp. 40-53.
APA	Famitafreshi H, Karimian M (2018). Morphine Addiction Is Tolerated Better in Socialized Male Rats. Sleep and Hypnosis, 20(1), 40-53.
Chicago	Famitafreshi H, Karimian M. "Morphine Addiction Is Tolerated Better in Socialized Male Rats." Sleep and Hypnosis 20, no. 1 (2018): 40-53.
Harvard	Famitafreshi H, Karimian M (2018) 'Morphine Addiction Is Tolerated Better in Socialized Male Rats', Sleep and Hypnosis, 20(1), pp. 40-53.
Vancouver	Famitafreshi H, Karimian M. Morphine Addiction Is Tolerated Better in Socialized Male Rats. Sleep and Hypnosis. 2018;20(1):40-53.
BibTex	@article{ author = {Famitafreshi H and Karimian M}, title = {Morphine Addiction Is Tolerated Better in Socialized Male Rats}, journal = {Sleep and Hypnosis}, volume = {20}, number = {1}, pages = {40-53}, year = {2018} }
RIS	TY - JOUR AU - Famitafreshi H AU - Karimian M TI - Morphine Addiction Is Tolerated Better in Socialized Male Rats JO - Sleep and Hypnosis VL - 20 IS - 1 SP - 40 EP - 53 PY - 2018 ER -

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