Dclk1 Plays an Important Role in Colorectal Cancer Tumorgenesis Through the Regulation of Mir-200C

Dclk1 Plays an Important Role in Colorectal Cancer Tumorgenesis Through the Regulation of Mir-200C Publisher Pubmed

Mohammadi Y¹ ; Tavangar SM² ; Saidijam M¹ ; Amini R¹ ; Etemadi K¹ ; Karimi Dermani F¹ ; Najafi R¹

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1. Research center for molecular medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2. Department of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2018

Abstract

Doublecortin-like kinase 1 (DCLK1) is a protein kinase that is known as a specific cancer stem cell (CSC) marker in colorectal cancer (CRC). Deregulation of DCLK1 expression has been reported in various cancers. We measured the protein expression of DCLK1 in 38 CRC and normal colon samples by immunohistochemistry (IHC). HCT-116 and SW-48 cells were transfected with DCLK1 siRNA and analyzed for expression of DCLK1 and miR-200c. The effects of DCLK1 knockdown on cell migration, invasion, sphere-forming, and apoptosis were explored. It was found that DCLK1 protein expression levels were significantly higher in CRC tissue than in normal colon specimens. Silencing of DCLK1 significantly inhibited cell migration, invasion, and sphere-forming potential; it also induced apoptosis as well as increased expression of miR-200c. Furthermore, silencing of miR-200c significantly up-regulated DCLK1 expression. Overall, our data demonstrated that DCLK1 plays an important role in cancer progression and is involved in the regulation of miR-200c expression. © 2018 Elsevier Masson SAS

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Style	Citing Format
MLA	Mohammadi Y, et al.. "Dclk1 Plays an Important Role in Colorectal Cancer Tumorgenesis Through the Regulation of Mir-200C." Biomedicine and Pharmacotherapy, vol. 103, no. , 2018, pp. 301-307.
APA	Mohammadi Y, Tavangar SM, Saidijam M, Amini R, Etemadi K, Karimi Dermani F, Najafi R (2018). Dclk1 Plays an Important Role in Colorectal Cancer Tumorgenesis Through the Regulation of Mir-200C. Biomedicine and Pharmacotherapy, 103(), 301-307.
Chicago	Mohammadi Y, Tavangar SM, Saidijam M, Amini R, Etemadi K, Karimi Dermani F, Najafi R. "Dclk1 Plays an Important Role in Colorectal Cancer Tumorgenesis Through the Regulation of Mir-200C." Biomedicine and Pharmacotherapy 103, no. (2018): 301-307.
Harvard	Mohammadi Y et al. (2018) 'Dclk1 Plays an Important Role in Colorectal Cancer Tumorgenesis Through the Regulation of Mir-200C', Biomedicine and Pharmacotherapy, 103(), pp. 301-307.
Vancouver	Mohammadi Y, Tavangar SM, Saidijam M, Amini R, Etemadi K, Karimi Dermani F, et al.. Dclk1 Plays an Important Role in Colorectal Cancer Tumorgenesis Through the Regulation of Mir-200C. Biomedicine and Pharmacotherapy. 2018;103():301-307.
BibTex	@article{ author = {Mohammadi Y and Tavangar SM and Saidijam M and Amini R and Etemadi K and Karimi Dermani F and Najafi R}, title = {Dclk1 Plays an Important Role in Colorectal Cancer Tumorgenesis Through the Regulation of Mir-200C}, journal = {Biomedicine and Pharmacotherapy}, volume = {103}, number = {}, pages = {301-307}, year = {2018} }
RIS	TY - JOUR AU - Mohammadi Y AU - Tavangar SM AU - Saidijam M AU - Amini R AU - Etemadi K AU - Karimi Dermani F AU - Najafi R TI - Dclk1 Plays an Important Role in Colorectal Cancer Tumorgenesis Through the Regulation of Mir-200C JO - Biomedicine and Pharmacotherapy VL - 103 IS - SP - 301 EP - 307 PY - 2018 ER -

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