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Novel and Emerging Mutations of Sars-Cov-2: Biomedical Implications Publisher Pubmed



Mohammadi E1, 2 ; Shafiee F3 ; Shahzamani K4 ; Ranjbar MM5 ; Alibakhshi A6 ; Ahangarzadeh S7 ; Beikmohammadi L8 ; Shariati L8, 9 ; Hooshmandi S11 ; Ataei B7 ; Javanmard SH10
Authors
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Authors Affiliations
  1. 1. Applied Physiology Research Center, Cardiovascular Research Institute, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Core Research Facilities, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan Gastroenterology and Hepatology Research Center (lGHRC), Isfahan University of medical sciences, Isfahan, Iran
  5. 5. Razi Vaccine and Serum Research Institute, Agricultural Research, Education, and Extension Organization (AREEO), Karaj, Iran
  6. 6. Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  7. 7. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Department of Biochemistry, Erasmus University Medical Center, Rotterdam, Netherlands
  9. 9. Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, 14155-6559, Iran
  10. 10. Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  11. 11. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2021


Abstract

Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19. © 2021
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