Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction With White Blood Cells on Cancer Cell Growth

Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction With White Blood Cells on Cancer Cell Growth Publisher

Delshad B¹ ; Abadijoo H^{2, 3} ; Simaee H^{2, 3, 4} ; Khayamian MA^{2, 3} ; Ghaderinia M^{2, 3} ; Yazdanparast SM^{2, 3} ; Beheshti J¹ ; Shamsi K¹ ; Afkham MA¹ ; Mansouri S^{5, 6} ; Akbari ME¹ ; Abdolahad M^{2, 3, 7, 8}

Show Affiliations

1. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran
3. Nano Electronic Center of Excellence, Thin Film and Nano Electronics Lab, School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran
4. Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
5. Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
6. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
7. Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
8. UT&TUMS Cancer Electronics Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Breast Cancer Published:2024

Abstract

Background: Intraoperative radiation therapy (IORT), is a promising method which has been widely applied in breast cancer lumpectomy. Although its effect on destructing remaining cancer cells was approved, maintaining or draining post intraoperative radiation therapy wound fluids (PIWF) is challenging. Moreover, the roles of immune cells in interaction with PIWFs have not been studied before which is the main investigation of this paper. Methods: Surgical wound fluids were collected from 24 IDC patients one day after lumpectomy. The patients were divided into control and IORT groups. The collected wound fluids were centrifuged for 20 minutes at 2000 rpm. The concentration of tumor-associated cytokines and inflammasomes were recorded using the immunoassays. Results: PIWFs stimulate the residue of cancer cells in cavity sides causing disease progression. Here we have focused on the effect of PIWFs on the proactivation or deactivation of WBCs in the tumor bed environment. By sequential imaging in time-transient intervals from the interaction between WBCs and cancer cells, PIWFs have no additive proactivating effect on immune cells. Conclusion: PIWFs have significant roles in proliferation of cancer cells but did not show an observable role in pro-activating immune cells against cancer cells. The functions of immune cells did not show any independent proactivation in the presence of PIWFs with respect to their activation in the presence of blood serum. It seems that draining the PIWFs may be required. In future research, we will use tumor samples of the patients instead of cell lines to better investigate the personalized immune-tumor interactions of patients. Copyright © 2024.

Style	Citing Format
MLA	Delshad B, et al.. "Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction With White Blood Cells on Cancer Cell Growth." Archives of Breast Cancer, vol. 11, no. 1, 2024, pp. 89-95.
APA	Delshad B, Abadijoo H, Simaee H, Khayamian MA, Ghaderinia M, Yazdanparast SM, Beheshti J, Shamsi K, Afkham MA, Mansouri S, Akbari ME, Abdolahad M (2024). Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction With White Blood Cells on Cancer Cell Growth. Archives of Breast Cancer, 11(1), 89-95.
Chicago	Delshad B, Abadijoo H, Simaee H, Khayamian MA, Ghaderinia M, Yazdanparast SM, Beheshti J, et al.. "Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction With White Blood Cells on Cancer Cell Growth." Archives of Breast Cancer 11, no. 1 (2024): 89-95.
Harvard	Delshad B et al. (2024) 'Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction With White Blood Cells on Cancer Cell Growth', Archives of Breast Cancer, 11(1), pp. 89-95.
Vancouver	Delshad B, Abadijoo H, Simaee H, Khayamian MA, Ghaderinia M, Yazdanparast SM, et al.. Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction With White Blood Cells on Cancer Cell Growth. Archives of Breast Cancer. 2024;11(1):89-95.
BibTex	@article{ author = {Delshad B and Abadijoo H and Simaee H and Khayamian MA and Ghaderinia M and Yazdanparast SM and Beheshti J and Shamsi K and Afkham MA and Mansouri S and Akbari ME and Abdolahad M}, title = {Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction With White Blood Cells on Cancer Cell Growth}, journal = {Archives of Breast Cancer}, volume = {11}, number = {1}, pages = {89-95}, year = {2024} }
RIS	TY - JOUR AU - Delshad B AU - Abadijoo H AU - Simaee H AU - Khayamian MA AU - Ghaderinia M AU - Yazdanparast SM AU - Beheshti J AU - Shamsi K AU - Afkham MA AU - Mansouri S AU - Akbari ME AU - Abdolahad M TI - Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction With White Blood Cells on Cancer Cell Growth JO - Archives of Breast Cancer VL - 11 IS - 1 SP - 89 EP - 95 PY - 2024 ER -

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