Macrophage’S Role in Solid Tumors: Two Edges of a Sword

Macrophage’S Role in Solid Tumors: Two Edges of a Sword Publisher

Jahandideh A^{1, 2} ; Yarizadeh M³ ; Noeikhesht Masjedi M⁴ ; Fatehnejad M⁵ ; Jahandideh R¹ ; Soheili R⁶ ; Eslami Y⁷ ; Zokaei M⁸ ; Ahmadvand A⁹ ; Ghalamkarpour N¹⁰ ; Kumar Pandey R¹¹ ; Nabi Afjadi M¹² ; Payandeh Z¹¹

Show Affiliations

1. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
2. Usern Office, Mazandaran University of Medical Sciences, Sari, Iran
3. Islamic Azad University, Tehran Medical Branch, Tehran, Iran
4. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad University, Tehran, Iran
7. Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
8. Department of Food Science and Technology, Faculty of Nutrition Science, Food Science and Technology/National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
9. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
10. Department of Clinical Laboratory Sciences, School of Allied Medicine, Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
11. Department Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden
12. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Source: Cancer Cell International Published:2023

Abstract

The tumor microenvironment is overwhelmingly dictated by macrophages, intimately affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis, extracellular matrix reconfiguration, cellular proliferation, metastasis, and immunosuppression. They further exhibit resilience to chemotherapy and immunotherapy via meticulous checkpoint blockades. When appropriately stimulated, macrophages can morph into a potent bidirectional component of the immune system, engulfing malignant cells and annihilating them with cytotoxic substances, thus rendering them intriguing candidates for therapeutic targets. As myelomonocytic cells relentlessly amass within tumor tissues, macrophages rise as prime contenders for cell therapy upon the development of chimeric antigen receptor effector cells. Given the significant incidence of macrophage infiltration correlated with an unfavorable prognosis and heightened resistance to chemotherapy in solid tumors, we delve into the intricate role of macrophages in cancer propagation and their promising potential in confronting four formidable cancer variants—namely, melanoma, colon, glioma, and breast cancers. © 2023, The Author(s).

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Style	Citing Format
MLA	Jahandideh A, et al.. "Macrophage’S Role in Solid Tumors: Two Edges of a Sword." Cancer Cell International, vol. 23, no. 1, 2023, pp. -.
APA	Jahandideh A, Yarizadeh M, Noeikhesht Masjedi M, Fatehnejad M, Jahandideh R, Soheili R, Eslami Y, Zokaei M, Ahmadvand A, Ghalamkarpour N, Kumar Pandey R, Nabi Afjadi M, Payandeh Z (2023). Macrophage’S Role in Solid Tumors: Two Edges of a Sword. Cancer Cell International, 23(1), -.
Chicago	Jahandideh A, Yarizadeh M, Noeikhesht Masjedi M, Fatehnejad M, Jahandideh R, Soheili R, Eslami Y, et al.. "Macrophage’S Role in Solid Tumors: Two Edges of a Sword." Cancer Cell International 23, no. 1 (2023): -.
Harvard	Jahandideh A et al. (2023) 'Macrophage’S Role in Solid Tumors: Two Edges of a Sword', Cancer Cell International, 23(1), pp. -.
Vancouver	Jahandideh A, Yarizadeh M, Noeikhesht Masjedi M, Fatehnejad M, Jahandideh R, Soheili R, et al.. Macrophage’S Role in Solid Tumors: Two Edges of a Sword. Cancer Cell International. 2023;23(1):-.
BibTex	@article{ author = {Jahandideh A and Yarizadeh M and Noeikhesht Masjedi M and Fatehnejad M and Jahandideh R and Soheili R and Eslami Y and Zokaei M and Ahmadvand A and Ghalamkarpour N and Kumar Pandey R and Nabi Afjadi M and Payandeh Z}, title = {Macrophage’S Role in Solid Tumors: Two Edges of a Sword}, journal = {Cancer Cell International}, volume = {23}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Jahandideh A AU - Yarizadeh M AU - Noeikhesht Masjedi M AU - Fatehnejad M AU - Jahandideh R AU - Soheili R AU - Eslami Y AU - Zokaei M AU - Ahmadvand A AU - Ghalamkarpour N AU - Kumar Pandey R AU - Nabi Afjadi M AU - Payandeh Z TI - Macrophage’S Role in Solid Tumors: Two Edges of a Sword JO - Cancer Cell International VL - 23 IS - 1 SP - EP - PY - 2023 ER -

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