Creb-Binding Protein (Crebbp) and Preeclampsia: A New Promising Target Gene

Creb-Binding Protein (Crebbp) and Preeclampsia: A New Promising Target Gene Publisher Pubmed

Sadeghi H¹ ; Esmkhani S^{2, 3} ; Pirjani R⁴ ; Aminbeidokhti M² ; Gholami M⁵ ; Azizi Tabesh G² ; Ghasemi MR² ; Gachkar L⁶ ; Mirfakhraie R^{1, 2}

Show Affiliations

1. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Koodakyar St., Velenjak Ave, Chamran Highway, Tehran, Iran
3. Department of Cancer Genetics, Oncology Institute, Istanbul University, Istanbul, Turkey
4. Obstetrics and Gynecology Department, Arash Women Hospital, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Biochemistry and Genetics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
6. Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Molecular Biology Reports Published:2021

Abstract

Preeclampsia (PE) is a major complication of pregnancy and remains a leading cause of neonatal and maternal mortality worldwide. Several studies have revealed that the incidence of preeclampsia is high in mothers who carried a fetus with Rubinstein-Taybi Syndrome due to the mutation in CREBBP. We aimed to compare the expression level of the CERBBP gene between preeclamptic and healthy placenta in our study. The expression level of CREBBP gene was evaluated in a total of one hundred placental biopsies from PE patients and healthy pregnant women after delivery using quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, the differential expression of CREBBP was assessed between the maternal and fetal sides of the placenta. Expression of the CREBBP gene was higher in preeclampsia patients compared with the controls (Fold change = 2.158; P = 0.018). Moreover, the gene expression was slightly higher in the fetal side of the placenta, although it was not significantly different (Fold change = 1.713, P = 0.254). Our findings show a role for CREBBP in the pathogenesis of PE. Due to the important role of CREBBP in angiogenesis and hypoxia, the gene may serve as a promising target in future studies. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.

Style	Citing Format
MLA	Sadeghi H, et al.. "Creb-Binding Protein (Crebbp) and Preeclampsia: A New Promising Target Gene." Molecular Biology Reports, vol. 48, no. 3, 2021, pp. 2117-2122.
APA	Sadeghi H, Esmkhani S, Pirjani R, Aminbeidokhti M, Gholami M, Azizi Tabesh G, Ghasemi MR, Gachkar L, Mirfakhraie R (2021). Creb-Binding Protein (Crebbp) and Preeclampsia: A New Promising Target Gene. Molecular Biology Reports, 48(3), 2117-2122.
Chicago	Sadeghi H, Esmkhani S, Pirjani R, Aminbeidokhti M, Gholami M, Azizi Tabesh G, Ghasemi MR, Gachkar L, Mirfakhraie R. "Creb-Binding Protein (Crebbp) and Preeclampsia: A New Promising Target Gene." Molecular Biology Reports 48, no. 3 (2021): 2117-2122.
Harvard	Sadeghi H et al. (2021) 'Creb-Binding Protein (Crebbp) and Preeclampsia: A New Promising Target Gene', Molecular Biology Reports, 48(3), pp. 2117-2122.
Vancouver	Sadeghi H, Esmkhani S, Pirjani R, Aminbeidokhti M, Gholami M, Azizi Tabesh G, et al.. Creb-Binding Protein (Crebbp) and Preeclampsia: A New Promising Target Gene. Molecular Biology Reports. 2021;48(3):2117-2122.
BibTex	@article{ author = {Sadeghi H and Esmkhani S and Pirjani R and Aminbeidokhti M and Gholami M and Azizi Tabesh G and Ghasemi MR and Gachkar L and Mirfakhraie R}, title = {Creb-Binding Protein (Crebbp) and Preeclampsia: A New Promising Target Gene}, journal = {Molecular Biology Reports}, volume = {48}, number = {3}, pages = {2117-2122}, year = {2021} }
RIS	TY - JOUR AU - Sadeghi H AU - Esmkhani S AU - Pirjani R AU - Aminbeidokhti M AU - Gholami M AU - Azizi Tabesh G AU - Ghasemi MR AU - Gachkar L AU - Mirfakhraie R TI - Creb-Binding Protein (Crebbp) and Preeclampsia: A New Promising Target Gene JO - Molecular Biology Reports VL - 48 IS - 3 SP - 2117 EP - 2122 PY - 2021 ER -

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