Rapid Microwave-Assisted Synthesis of Pvp-Coated Ultrasmall Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging

Rapid Microwave-Assisted Synthesis of Pvp-Coated Ultrasmall Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging Publisher

Vahdatkhah P¹ ; Madaah Hosseini HR¹ ; Khodaei A¹ ; Montazerabadi AR³ ; Irajirad R² ; Oghabian MA^{2, 3} ; Delavari H H⁴

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1. Department of Materials Science and Engineering, Sharif University of Technology, Iran
2. Biomolecular Image Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Iran
3. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Iran
4. Department of Materials Engineering, Tarbiat Modares University, PO Box 14115-143, Tehran, Iran

Source: Chemical Physics Published:2015

Abstract

Synthesis of polyvinyl pyrrolidone (PVP) coated ultrasmall Gd2O3 nanoparticles (NPs) with enhanced T1-weighted signal intensity and r2/r1 ratio close to unity is performed by a microwave-assisted polyol process. PVP coated Gd2O3NPs with spherical shape and uniform size of 2.5 ± 0.5 nm have been synthesized below 5 min and structure and morphology confirmed by HRTEM, XRD and FTIR. The longitudinal (r1) and transversal relaxation (r2) of Gd2O3NPs is measured by a 3 T MRI scanner. The results showed considerable increasing of relaxivity for Gd2O3NPs in comparison to gadolinium chelates which are commonly used for clinical magnetic resonance imaging. In addition, a mechanism for Gd2O3NPs formation and in situ surface modification of PVP-grafted Gd2O3NPs is proposed. © 2015 Elsevier B.V. All rights reserved.

Style	Citing Format
MLA	Vahdatkhah P, et al.. "Rapid Microwave-Assisted Synthesis of Pvp-Coated Ultrasmall Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging." Chemical Physics, vol. 453-454, no. , 2015, pp. 35-41.
APA	Vahdatkhah P, Madaah Hosseini HR, Khodaei A, Montazerabadi AR, Irajirad R, Oghabian MA, Delavari H H (2015). Rapid Microwave-Assisted Synthesis of Pvp-Coated Ultrasmall Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging. Chemical Physics, 453-454(), 35-41.
Chicago	Vahdatkhah P, Madaah Hosseini HR, Khodaei A, Montazerabadi AR, Irajirad R, Oghabian MA, Delavari H H. "Rapid Microwave-Assisted Synthesis of Pvp-Coated Ultrasmall Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging." Chemical Physics 453-454, no. (2015): 35-41.
Harvard	Vahdatkhah P et al. (2015) 'Rapid Microwave-Assisted Synthesis of Pvp-Coated Ultrasmall Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging', Chemical Physics, 453-454(), pp. 35-41.
Vancouver	Vahdatkhah P, Madaah Hosseini HR, Khodaei A, Montazerabadi AR, Irajirad R, Oghabian MA, et al.. Rapid Microwave-Assisted Synthesis of Pvp-Coated Ultrasmall Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging. Chemical Physics. 2015;453-454():35-41.
BibTex	@article{ author = {Vahdatkhah P and Madaah Hosseini HR and Khodaei A and Montazerabadi AR and Irajirad R and Oghabian MA and Delavari H H}, title = {Rapid Microwave-Assisted Synthesis of Pvp-Coated Ultrasmall Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging}, journal = {Chemical Physics}, volume = {453-454}, number = {}, pages = {35-41}, year = {2015} }
RIS	TY - JOUR AU - Vahdatkhah P AU - Madaah Hosseini HR AU - Khodaei A AU - Montazerabadi AR AU - Irajirad R AU - Oghabian MA AU - Delavari H H TI - Rapid Microwave-Assisted Synthesis of Pvp-Coated Ultrasmall Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging JO - Chemical Physics VL - 453-454 IS - SP - 35 EP - 41 PY - 2015 ER -

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