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Gadolinium Nanoparticles As Diagnostic and Therapeutic Agents: Their Delivery Systems in Magnetic Resonance Imaging and Neutron Capture Therapy Publisher



Narmani A1 ; Farhood B2 ; Haghiaminjan H3 ; Mortezazadeh T4 ; Aliasgharzadeh A2 ; Mohseni M2 ; Najafi M5 ; Abbasi H6
Authors
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Authors Affiliations
  1. 1. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, 1439957131, Iran
  2. 2. Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Medical Physics and Medical Engineering Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Science, Kermanshah, Iran
  6. 6. MSC Microbiology Department, Islamic Azad University, North Tehran Branch, Tehran, 16679141-61, Iran

Source: Journal of Drug Delivery Science and Technology Published:2018


Abstract

Gadolinium (Gd) chelates have been widely used as contrast agent in magnetic resonance imaging (MRI). In addition to using MRI, they are interesting, as a radiosensitizer, in neutron capture therapy (NCT). However, the poor selective tissue labeling and localization provided by conventional molecular Gd chelates have confined success in both MRI and NCT applications. To encapsulate Gd into nanoparticulate materials can be considered as a method to overcome these limitations. In this regard, developing various carrier systems have increased the sensitivity and improving the targetability of the contrast agents. In this review article, an overview of the delivery systems of Gd nanoparticles in the MRI and NCT would be mentioned. © 2018 Elsevier B.V.
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