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Syntehsis and Evaluation of Gd3+ -Trp-Plga As Novel Nanosized Mr Tumor Imaging Candidate Publisher



Salehian E1 ; Safa R2 ; Saffari M2 ; Ashrafi S3 ; Farhoudi R4 ; Ebrahimi SES5 ; Hamedani MP5 ; Mirzaei M6 ; Ardestani MS1
Authors
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Authors Affiliations
  1. 1. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmaceutics and Medical Nanotechnology, Branch of Pharmaceutical Sciences, Islamic Azad University, Tehran, Iran
  3. 3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Quality Control Department, Pasteur Institute of Iran, Iran
  5. 5. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Iran ministry of health and medical education, deputy ministry for education, Tehran, Iran

Source: Nanomedicine Journal Published:2021


Abstract

Objective(s): Early detection of cancer can significantly increase the likelihood of successful treatment, and imaging assay can have a significant impact on cancer diagnosis. Although gadolinium compounds are used as a contrast agent in MRI, this substance has side effects and disadvantages. Nanotechnology has so far had a significan impact on medical imaging methods, especially MRI, nanoparticles are contrast enhancers that Each with its characteristics have increased the quality of images and reduced toxicity. Materials and Methods: In this study, a novel nano-conjugate based PLGA-tryptophan was synthesized and loaded with Gd3+ for using it as a potential MR imaging contrast agent to overcome the previous disadvantage. In vitro cell toxicity, cellular uptake and MR imaging parameters of the prepared nanoconjugate were investigated , Results: The results showed no in vivo toxicity plus flowcytometry assays, good cellular uptake and large longitudinal (r1). Conclusion: Convenient features of the nano-probe indicate that it is a promising agent to use as a MR imaging agent. © 2021 Mashhad University of Medical Sciences. All Rights Reserved.
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