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Vegf Gene Polymorphisms in Iranian Patients With Intracranial Glioblastoma Publisher Pubmed



Hanaei S1, 2 ; Mojtahedi H3, 4 ; Namvar M1 ; Iranmehr A1 ; Safaei R5 ; Razavi A6 ; Esmaeili M6 ; Sadr M3 ; Rezaei A6 ; Edalatfar M7 ; Kashani HK7 ; Sadeghinaini M8 ; Darbeheshti F9 ; Gharehdaghi J10 Show All Authors
Authors
  1. Hanaei S1, 2
  2. Mojtahedi H3, 4
  3. Namvar M1
  4. Iranmehr A1
  5. Safaei R5
  6. Razavi A6
  7. Esmaeili M6
  8. Sadr M3
  9. Rezaei A6
  10. Edalatfar M7
  11. Kashani HK7
  12. Sadeghinaini M8
  13. Darbeheshti F9
  14. Gharehdaghi J10
  15. Forouzesh M10
  16. Ebrahimi A11
  17. Rezaei N4, 6, 11, 12
Show Affiliations
Authors Affiliations
  1. 1. Department of Neurosurgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Network of Immunity in Infection Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  6. 6. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Neurosurgery, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Neurosurgery, Lorestan University of Medical Sciences, Khorram Abad, Iran
  9. 9. School of Medicine, Department of Genetics, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
  11. 11. School of Medicine, Department of Pathology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  12. 12. School of Medicine, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Neurosurgical Sciences Published:2024


Abstract

BACKGROUND: Glioblastoma is one of the most common malignant brain tumors in adults with poor prognosis. Neovascularization is one of the characteristics of these tumors, which is associated with overexpression of vascular endothelial growth factor (VEGF). Accordingly, single nucleotide polymorphisms of this gene could play an important role in structural and functional alterations leading to overexpression of this gene in GBM. METHODS: Atotal number of 49 patients with GBM and 50 healthy controls were included in the current study. The Genomic DNAwas extracted from brain tumor/tissue samples, and after purification assessment, the alleles, and genotypes of rs3025039 and rs2010963 polymorphisms of the VEGFgene were investigated using T-ARMS-PCR. RESULTS: The T allele of rs3025039 was 2.79 times more frequent in GBM patients compared to controls (P=0.01). Moreover, the CT genotype was 2.83 times more common among patients (P=0.015), while the CC was more frequent in controls (P=0.009). The mean overall survival was significantly different between three genotypes of rs3025039, with the longest survival time in CT genotype (15.10±5.21, P=0.041). Besides, rs2010963, was significantly associated with GBM occurrence, with the G allele being 1.96 times more frequent in patients (P=0.01), as well as the GG genotype, which was 7.87 times more common in patients (P<0.001). CONCLUSIONS: Polymorphisms of VEGFcould potentially play a role in pathogenesis of GBM, as the allele and genotype distributions of rs3025039 and rs2010963 SNPs were significantly associated with GBM occurrence. © 2024 Edizioni Minerva Medica. All rights reserved.
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