Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Vegf Levels in Patients With Glioma: A Systematic Review and Meta-Analysis Publisher Pubmed



Seyedmirzaei H1, 2 ; Shobeiri P1, 2 ; Turgut M3, 4 ; Hanaei S1, 2 ; Rezaei N1, 2, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences (TUMS), Children's Medical Center Hospital, Dr. Qarib St., Keshavarz Blvd, Tehran, 14194, Iran
  2. 2. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Department of Neurosurgery, Aydln Adnan Menderes University, Faculty of Medicine, Efeler, Aydln, Turkey
  4. 4. Department of Histology and Embryology, Aydln Adnan Menderes University, Health Sciences Institute, Efeler, Aydln, Turkey
  5. 5. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Reviews in the Neurosciences Published:2021


Abstract

Vascular endothelial growth factor (VEGF) has a crucial role in the angiogenesis of various tumors, including glioma. As the levels of VEGF would change in patients with glioma, we conducted the current systematic review and meta-analysis to more clearly determine the VEGF level alterations in different grades of glioma. PubMed and Scopus databases were sensitively searched for all the possible keywords addressing glioma and VEGF. Case-control and cohort studies on human subjects, which measured VEGF levels were eligible to be included in the study. Out of a total number of 3,612 studies, 22 studies were included and 12 studies entered the meta-analysis. This review revealed that serum levels of VEGF in glioma patients were 1.56 pg/dL higher compared to healthy controls (P = 0.05). Besides, immunohistochemistry (IHC) measurement of VEGF in surgical biopsies indicated significant difference in these two groups as well (P = 0.02). Yet, there was not a significant difference between patients with low-grade gliomas (World Health Organization (WHO) grades I-II, LGG) and those with high-grade gliomas (WHO grades III-IV, HGG) (P = 0.43). The results of this systematic review and meta-analysis demonstrate that VEGF levels would significantly increase in glioma, and therefore, could be potentially considered as a biomarker for this cancer. © 2020 Walter de Gruyter GmbH, Berlin/Boston 2020.
Related Docs
1. Gastric Cancer Risk in Association With Underweight, Overweight, and Obesity: A Systematic Review and Meta-Analysis, Cancers (2023)
2. Dietary Total Antioxidant Capacity and Risk of Cancer: A Systematic Review and Meta-Analysis on Observational Studies, Critical Reviews in Oncology/Hematology (2019)
3. Association of Total Nut, Tree Nut, Peanut, and Peanut Butter Consumption With Cancer Incidence and Mortality: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Observational Studies, Advances in Nutrition (2021)
4. Angioregulatory Role of Mirnas and Exosomal Mirnas in Glioblastoma Pathogenesis, Biomedicine and Pharmacotherapy (2022)
Experts (# of related papers)
Morteza Nasiri (2)