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Localized Delivery of Healing Stimulator Medicines for Enhanced Wound Treatment Publisher



Almusawi MH1 ; Turki S2 ; Alnaymi HAS3 ; Sameer Alsalman S1 ; Boroujeni VV4 ; Alizadeh M5 ; Sattar M6 ; Sharifianjazi F7, 8 ; Bazli L9 ; Pajooh AMD10 ; Shahriarikhalaji M11 ; Najafinezhad A12 ; Moghadam FM13 ; Mirhaj M14 Show All Authors
Authors
  1. Almusawi MH1
  2. Turki S2
  3. Alnaymi HAS3
  4. Sameer Alsalman S1
  5. Boroujeni VV4
  6. Alizadeh M5
  7. Sattar M6
  8. Sharifianjazi F7, 8
  9. Bazli L9
  10. Pajooh AMD10
  11. Shahriarikhalaji M11
  12. Najafinezhad A12
  13. Moghadam FM13
  14. Mirhaj M14
  15. Tavakoli M14
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Laboratory Sciences, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq
  2. 2. Department of Plant Biotechnology College of Biotechnology, Al-Nahrain University, Baghdad, Iraq
  3. 3. Department of Chemistry, College of Education for Pure Science/Ibn Al-Haitham, University of Baghdad, Baghdad, Iraq
  4. 4. Department of Food and Drug Control, School of Pharmacy, Tehran University of Medical Sciences, Iran
  5. 5. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  6. 6. College of Biological Science and Medical Engineering, Donghua University, No. 2999 North Renmin Road, Shanghai, 201620, China
  7. 7. Center for Advanced Materials and Structures, School of Science and Technology, The University of Georgia, Tbilisi, 0171, Georgia
  8. 8. Department of Civil Engineering, School of Science and Technology, The University of Georgia, Tbilisi, 0171, Georgia
  9. 9. School of Science and Technology, The University of Georgia, Tbilisi, Georgia
  10. 10. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
  11. 11. Department of Biomedical Engineering, Rowan University, Glassboro, 08028, NJ, United States
  12. 12. Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
  13. 13. Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Cambridge, 02139, MA, United States
  14. 14. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran

Source: Journal of Drug Delivery Science and Technology Published:2024


Abstract

Wound healing, as one of the most complex biological processes, involves a cascade of molecular and cellular mechanisms. Delayed repair and bacterial infections can complicate this process, leading to prolonged inflammation, chronicity, and in severe cases, resulting in amputation or death of the patient. In recent years, biomedical scientists and physicians have achieved notable progress in understanding the importance of crucial antibiotics, anti-inflammatories, angiogenesis regulators and healing stimulant medications in wound healing. Although the importance of harnessing antibiotics has been discussed in many studies, other pharmacological agents that influence wound healing including angiogenesis and inflammation modulators have received less attention. Localized delivery of these therapeutics promotes vascularization and cellular activity, which is versatile approach to expedite the wound repair process, while increasing efficacy and reducing side effects. Localized drug delivery to the wound site can be carried out through various methods, such as nanofibers, hydrogels, nanoparticles, micelles, liposomes, exosomes, niosomes, microspheres and microneedles. This review underscores the indispensable potential of some lesser-known antibiotics, angiogenesis regulators, inflammation modulators, phytochemicals and healing stimulators, as strategic components in wound healing process, and reveals their significance, molecular mechanisms and functional pathways. This provides valuable insights for future research endeavors and clinical implications aimed at optimizing wound care. © 2024 Elsevier B.V.
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