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In-Vitro and In-Vivo Evaluation of Angiogenic Potential of a Novel Lithium Chloride Loaded Silk Fibroin / Alginate 3D Porous Scaffold With Antibacterial Activity, for Promoting Diabetic Wound Healing Publisher Pubmed



Bashiri Z1, 2 ; Sharifi AM3, 4, 5 ; Ghafari M6 ; Hosseini SJ7, 8 ; Shahmahmoodi Z9, 10 ; Moeinzadeh A9, 10 ; Parsaei H11 ; Khadivi F12 ; Afzali A13 ; Koruji M1, 4
Authors
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Authors Affiliations
  1. 1. Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Omid Fertility & Infertility Clinic, Hamedan, Iran
  3. 3. Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Tissue Engineering Group (NOCERAL), Department of Orthopedics Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  6. 6. Department of Chemistry, Isfahan University of Technology, Isfahan, Iran
  7. 7. Biomedical Engineering Department, Amirkabir University of Technology, Tehran, Iran
  8. 8. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  11. 11. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
  12. 12. Department of Anatomy, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
  13. 13. Hajar hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: International Journal of Biological Macromolecules Published:2024


Abstract

Healing diabetic ulcers with chronic inflammation is a major challenge for researchers and professionals, necessitating new strategies. To rapidly treat diabetic wounds in rat models, we have fabricated a composite scaffold composed of alginate (Alg) and silk fibroin (SF) as a wound dressing that is laden with molecules of lithium chloride (LC). The physicochemical, bioactivity, and biocompatibility properties of Alg-SF-LC scaffolds were investigated in contrast to those of Alg, SF, and Alg-SF ones. Afterward, full-thickness wounds were ulcerated in diabetic rats in order to evaluate the capacity of LC-laden scaffolds to regenerate skin. The characterization findings demonstrated that the composite scaffolds possessed favorable antibacterial properties, cell compatibility, high swelling, controlled degradability, and good uniformity in the interconnected pore microstructure. Additionally, in terms of wound contraction, re-epithelialization, and angiogenesis improvement, LC-laden scaffolds revealed better performance in diabetic wound healing than the other groups. This research indicates that utilizing lithium chloride molecules loaded in biological materials supports the best diabetic ulcer regeneration in vivo, and produces a skin replacement with a cellular structure comparable to native skin. © 2024
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