Expression Analysis of Inhibitor of Dna Binding 1 (Id-1) Gene in Breast Cancer

Expression Analysis of Inhibitor of Dna Binding 1 (Id-1) Gene in Breast Cancer Publisher Pubmed

Shams R¹ ; Geranpayeh L² ; Omrani MD³ ; Ghafourifard S¹

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1. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran
2. Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
3. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Human Antibodies Published:2019

Abstract

BACKGROUND: ID-1 gene codes for a helix-loop-helix (HLH) protein that inhibits the DNA binding and transcriptional activation function of these proteins. METHODS: We analyzed ID-1 expression in microarray and RNA Sequencing databases as well as 61 breast cancer tissues compared with adjacent non-cancerous tissues (ANCTs). RESULTS: Expression analysis of ID-1 gene in two microarray datasets and RNA sequencing data showed down-regulation of ID-1 in tumoral tissues compared with normal tissues. However, ID-1 expression analysis in tumoral tissues and ANCTs obtained from 61 patients revealed its over-expression in tumoral tissues. A negative association was detected between ID-1 expression levels and ER status. CONCLUSION: ID-1 expression may be implicated in the pathogenesis of breast cancer especially in patient with ER negative status. © 2019 - IOS Press and the authors.

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Style	Citing Format
MLA	Shams R, et al.. "Expression Analysis of Inhibitor of Dna Binding 1 (Id-1) Gene in Breast Cancer." Human Antibodies, vol. 27, no. 2, 2019, pp. 129-134.
APA	Shams R, Geranpayeh L, Omrani MD, Ghafourifard S (2019). Expression Analysis of Inhibitor of Dna Binding 1 (Id-1) Gene in Breast Cancer. Human Antibodies, 27(2), 129-134.
Chicago	Shams R, Geranpayeh L, Omrani MD, Ghafourifard S. "Expression Analysis of Inhibitor of Dna Binding 1 (Id-1) Gene in Breast Cancer." Human Antibodies 27, no. 2 (2019): 129-134.
Harvard	Shams R et al. (2019) 'Expression Analysis of Inhibitor of Dna Binding 1 (Id-1) Gene in Breast Cancer', Human Antibodies, 27(2), pp. 129-134.
Vancouver	Shams R, Geranpayeh L, Omrani MD, Ghafourifard S. Expression Analysis of Inhibitor of Dna Binding 1 (Id-1) Gene in Breast Cancer. Human Antibodies. 2019;27(2):129-134.
BibTex	@article{ author = {Shams R and Geranpayeh L and Omrani MD and Ghafourifard S}, title = {Expression Analysis of Inhibitor of Dna Binding 1 (Id-1) Gene in Breast Cancer}, journal = {Human Antibodies}, volume = {27}, number = {2}, pages = {129-134}, year = {2019} }
RIS	TY - JOUR AU - Shams R AU - Geranpayeh L AU - Omrani MD AU - Ghafourifard S TI - Expression Analysis of Inhibitor of Dna Binding 1 (Id-1) Gene in Breast Cancer JO - Human Antibodies VL - 27 IS - 2 SP - 129 EP - 134 PY - 2019 ER -

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