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Expression and Clinicopathological Significance of Aoc4p, Prncr1, and Pcat1 Lncrnas in Breast Cancer Publisher Pubmed



Abdollahzadeh R1 ; Mansoori Y2 ; Azarnezhad A3 ; Daraei A4 ; Paknahad S1 ; Mehrabi S1 ; Tabei MB5 ; Jafari D6 ; Shakoori A1 ; Tavakkolybazzaz J1
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  4. 4. Department of Medical Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
  5. 5. Department of Medical Genetics, School of Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Pathology Research and Practice Published:2020


Abstract

Long none coding RNAs (lncRNAs) AOC4P, PRNCR1, and PCAT-1 are dysregulated in various types of malignancies. However, their expression and clinicopathological significances are uncertain in breast cancer (BC). Quantitative real-time polymerase chain reaction (RT- qPCR) was used to measure the expression levels of the selected lncRNAs in tumor tissues obtained from 50 BC patients compared to the normal adjacent tissues (NATs) and 50 clinically healthy normal tissues. Our results revealed a significant downregulation of AOC4P, however, upregulated PRNCR1 and PCAT1 were found in tumor tissues compared to NATs and clinically healthy normal tissues (P < 0.05). Interestingly, remarkable decreased expression of AOC4P was observed in NATs than clinically healthy normal tissues. Dysregulation of the lncRNAs was correlated with worse outcomes of patients. Furthermore, our data showed that the altered expression levels of lncRNAs AOC4P, PRNCR1, and PCAT1 might be occurred through the function of demographic and reproductive variables. Taken together, the altered regulation of AOC4P, PRNCR1, and PCAT1 may highlight their crucial roles in BC development and pathogenesis. Our findings also proposed demographic and reproductive variables as risk factors in BC through the possible influence on the expression of the studied lncRNAs. Nevertheless, further explorations are required to elucidate the more detailed functions of these lncRNAs in BC. © 2020
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