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The Nlrp1 Emerges As a Promising Therapeutic Target and Prognostic Biomarker Across Multiple Cancer Types: A Comprehensive Pan-Cancer Analysis Publisher Pubmed



Habibipour L1 ; Sadeghi M1, 2, 3 ; Raghibi A4 ; Sanadgol N5 ; Mohajeri Khorasani A6, 7, 8 ; Mousavi P1
Authors
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Authors Affiliations
  1. 1. Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  2. 2. Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  3. 3. Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Institute of Neuroanatomy, RWTH University Hospital Aachen, Aachen, Germany
  6. 6. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Cancer Medicine Published:2025


Abstract

Introduction: Nod-like receptor family pyrin domain containing 1 (NLRP1) serves as the central component of the inflammasome complex and has emerged as a potential contributor to cancer development. Despite accumulating evidence, a comprehensive assessment of NLRP1 across various cancer types has yet to be undertaken. Methods: Several databases have evaluated NLRP1 expression across various cancer types in The Cancer Genome Atlas (TCGA). Additionally, studies have investigated the correlation between NLRP1 and various survival metrics, infiltration of cancer-associated fibroblasts, genetic alterations, drug sensitivity, and promoter methylation. Furthermore, research has explored the potential roles of NLRP1 and its interactions with other proteins. Results: Our analysis revealed decreased expression of NLRP1 in BLCA, BRCA, KICH, LUAD, LUSC, PRAD, and UCEC tumor tissues compared to normal tissues. We identified a significant correlation between NLRP1 expression and various cancer survival parameters, genetic mutations, and immune infiltration of cancer-associated fibroblasts. Furthermore, we observed that NLRP1 expression is regulated by promoter DNA methylation in ESCA. Abnormal expression of NLRP1 was associated with decreased sensitivity to multiple anti-tumor drugs and small compounds. NLRP1 was found to be involved in pathways associated with T cell receptors and chemokines. Conclusions: Reduced NLRP1 expression contributes to cancer progression and holds potential as a crucial biomolecular marker for diagnostic, prognostic, and personalized therapeutic interventions across different malignancies. © 2025 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.
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